f Influence of iron restriction on Chlamydia pneumoniae and C. trachomatis
- Authors: HEIKE M. FREIDANK1, HEIKO BILLING1, MARGIT WIEDMANN-AL-AHMAD1
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1 Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germany
- Corresponding author: Dr H.M. Freidank (e-mail: email@example.com).
- First Published Online: 01 March 2001, Journal of Medical Microbiology 50: 223-227, doi: 10.1099/0022-1317-50-3-223
- Subject: Bacterial Pathogenicity
- Issue Published:
Iron is an essential metabolite for pathogenic bacteria, and the specificity exhibited by bacteria for host-iron chelates may be correlated with host and tissue tropism. The effect of iron restriction on Chlamydia pneumoniae and C. trachomatis was studied by use of the iron-chelating compound deferoxamine. Growth of C. pneumoniae was inhibited much more than that of C. trachomatis and the effect of iron restriction largely depended on the cell line used for propagation. This might reflect differences in tissue tropism of the two chlamydial species. As iron levels are usually higher in men than in women, this might also be connected with the higher prevalence rate of C. pneumoniae antibodies in males, observed in all populations studied so far.
Received 21 Nov. 1999; revised version accepted 7 Aug. 2000.
© 2001 Society for General Microbiology | Published by the Microbiology Society
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