1887

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Volume 1, Issue 1

The chemical composition and capacity for protein synthesis of the liver of cattle suffering from clinical Johne’s disease Free

Abstract

Summary

Liver tissue was obtained from 5 cases of clinical Johne’s disease by biopsy and analysed for total nitrogen, protein nitrogen, “collagen”, lipid, nucleic acids, acid-soluble ribonucleotides and ATP. Comparisons were made with liver tissue from healthy cows. The only significant changes in chemical composition were a small rise in liver lipid content and a marked increase in tissue hydroxyproline, indicating increased connective tissue and suggesting early fibrosis.

The in-vitro rate of protein synthesis was assayed in 2 clinical cases and 3 controls by means of the rate of incorporation of [U-C] leucine into the proteins of liver slices. A higher than normal rate of synthesis was observed in the liver tissue from the cows with clinical Johne’s disease but, at the same time, tissue concentrations of three enzymes (glucose-6-phosphatase, hexose monophosphate dehydrogenase and lactate dehydrogenase) were lowered.

  • Received:
  • Accepted:
  • Published Online:
© 1968 E & S LIVINGSTONE LTD
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1968-08-01
2024-05-04
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The chemical composition and capacity for protein synthesis of the liver of cattle suffering from clinical Johne’s disease
J. Med. Microbiol. 1, 137 (1968); https://doi.org/10.1099/00222615-1-1-137
/content/journal/jmm/10.1099/00222615-1-1-137
/content/journal/jmm/10.1099/00222615-1-1-137
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