1887

Abstract

SUMMARY

The controversy regarding the possible role of genital mycoplasma infection in human reproductive failure gave rise to a study in which pregnant rats, previously shown to be of normal fertility, were inoculated 7-11 days after conception with either or an equal volume of sterile broth medium. Repeated observations during the course of pregnancy revealed several pathogenic effects.

A statistically significant decrease was observed in the mean litter size of infected mothers. Furthermore, the offspring showed low viability at birth and, still more, at 10 days after birth. Our data are compatible with the hypothesis that genital mycoplasma infection plays a role in reproductive failure.

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1978-08-01
2024-05-05
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References

  1. Beck D., Ginsburg H., Naot Y. 1977; The modulating effect of human chorionic gonadotrophin on lymphocyte blastogenesis. Am. J. Obstet. Gynec 129:14
    [Google Scholar]
  2. Braun P., Lee Y. H., Klein J. O., Marcy S. M., Klein T. A., Charles D., Levy P., Kass E. H. 1971; Birth weight and genital mycoplasmas in pregnancy. New Engl. J. Med 284:167
    [Google Scholar]
  3. Caspi E., Solomon F., Sompolinsky D. 1972; Early abortion and mycoplasma infection. Israel J. med. Sci 8:122
    [Google Scholar]
  4. Cole B. C., Golightly-Rowland L., Ward J. R. 1976; Arthritis of mice induced by Mycoplasma arthritidis. Humoral antibody and lymphocyte responses of CBA mice. Ann. rheum. Dis 35:14
    [Google Scholar]
  5. De Louvois J., Blades M., Harrison R. F., Hurley R., Stanley V. C. 1974; Frequency of mycoplasma in fertile and infertile couples. Lancet 1:1073
    [Google Scholar]
  6. Ganaway J. R., Allen A. M., Moore T. D., Bohner H. J. 1973; Natural infection of germfree rats with Mycoplasma pulmonis. J. infect. Dis. 127:529
    [Google Scholar]
  7. Harwick H. J., Iuppa J. B., Purcell R. H., Fekety F. R. 1967; Mycoplasma hominis septicemia associated with abortion. Am. J. Obstet. Gynec 99:725
    [Google Scholar]
  8. Hayflick L. 1965; Tissue cultures and mycoplasma. Tex. Rep. Biol. Med. Suppl. 1 23:285
    [Google Scholar]
  9. Jones D. M. 1967a; Mycoplasma hominis in pregnancy. J. clin. Path 20:633
    [Google Scholar]
  10. Jones D. M. 1967b; Mycoplasma hominis in abortion. Br. med. J 1:338
    [Google Scholar]
  11. Klein J. O., Buckland D., Finland M. 1969; Colonization of newborn infants by mycoplasmas. New Engl. J. Med 280:1025
    [Google Scholar]
  12. Klein A., Sharf M., Zilberman A., Ginsburg H., Naot Y. 1978; Mycoplasma infection in gravid rats: fetal infection and impaired weight increase during gestation. Harefuah 94:63
    [Google Scholar]
  13. Kundsin R. B., Driscoll S. G. 1970; Mycoplasma and human reproductive failure. Surgery Gynec. Obstet 131:89
    [Google Scholar]
  14. Lemcke R. M. 1964; The serological differentiation of mycoplasma strains (PPLO) from various sources. J. Hyg., Camb 62:199
    [Google Scholar]
  15. Naot Y., Tully J. G., Ginsburg H. 1977; Lymphocyte activation by various mycoplasma strains and species. Infect. Immun 18:310
    [Google Scholar]
  16. Taylor-Robinson D., Rassner C., Furr P. M., Humber D. P., Barnes R. D. 1975; Fetal wastage as a consequence of Mycoplasma pulmonis infection in mice. J. Reprod. Fert 42:483
    [Google Scholar]
  17. Tully J. G. 1965; Biochemical, morphological and serological characterization of mycoplasma of murine origin. J. infect. Dis 115:171
    [Google Scholar]
  18. Tully J. G. 1969; Murine mycoplasmas. In The mycoplasmatales and the L-phase of bacteria edited by Hayflick L. New York: p 571
    [Google Scholar]
  19. Ward J. R., Jones R. S. 1962; The pathogenesis of mycoplasma (PPLO) arthritis in rats. Arthritis Rheum 5:163
    [Google Scholar]
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