The Role of Alpha Haemolysin in the Virulence of Escherichia Coli for Mice
Linggood, Margaret A. and Ingram, P. L.,, 15, 23-30 (1982),
doi = https://doi.org/10.1099/00222615-15-1-23,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= SUMMARY Transfer of an Hly plasmid determining production of α haemolysin to a non-haemolytic strain of Escherichia coli increased the virulence of the strain for mice. Injections of non-toxic amounts of α haemolysin, phenylhydrazine, haemoglobin, iron or manganese salts simulated the effect of the Hly plasmid by stimulating bacterial growth. Active or passive immunisation against α haemolysin protected mice on challenge with haemolytic E. coli by inhibiting in-vivo proliferation of the strain. Protection was eliminated by administration of iron salts at the time of challenge. The Hly plasmid probably acts as a virulence factor by enabling haemolytic strains of E. coli to obtain iron for growth from the lysed erythrocytes of infected animals.,
language=,
type=