Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production Aldridge, K. E. and Sanders, C. V. and Lewis, A. C. and Marier, R. L.,, 16, 75-82 (1983), doi = https://doi.org/10.1099/00222615-16-1-75, publicationName = Microbiology Society, issn = 0022-2615, abstract= SUMMARY We examined the susceptibility of various anaerobes to four beta-lactamase susceptible (ampicillin, amoxycillin, cyclacillin, and penicillin G) and two beta-lactamase resistant (moxalactam, and N-F-thienamycin) beta-lactam antibiotics and measured beta-lactamase production. Members of the Bacteroides groups were most resistant to the six antibiotics. N-F-thienamycin was the most effective antimicrobial agent against all the test strains, moxalactam the next most effective, and penicillin G the least. Beta-lactamase production was mainly confined to Bacteroides species. Cephalosporinase was the most common beta-lactamase produced; penicillinase was detected less often. About two thirds of the penicillin-resistant isolates produced cephalosporinase. N-F-thienamycin and moxalactam were the most active agents against those anaerobes that were resistant to many beta-lactam antibiotics., language=, type=