1887

Abstract

SUMMARY

The virulence of 93 clinical isolates of was compared in a mouse model by subcutaneous injection. Skin pathogenicity was measured by estimating the number of viable bacteria in the lesions 24 h after infection with a dose of 10 bacteria. Strains of serotypes K1-6 were compared with strains of serotypes higher than K6. All K1 and K5, and some K2 and K4 strains were more virulent for mice than strains with a serotype higher than K6. The K3 strains were significantly less virulent than the strains with a serotype higher than K6. The bacteriological findings were confirmed by histological examination with some strains. No differences in virulence were observed between strains of the same serotype isolated from patients with cystitis or from those with pyelonephritis, nor between strains of the same serotype isolated from the blood of patients with septicaemia or from other sites. The mouse model has been found satisfactory for observing differences in virulence between isolates.

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1984-02-01
2024-04-20
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References

  1. Cowan S. T., Steel K. J., Shaw C., Duguid J. P. 1960; A classification of the Klebsiella group. Journal of General Microbiology 23:601–612
    [Google Scholar]
  2. Edmondson A. S., Cooke E. M. 1979; The production of antisera to the Klebsiella capsular antigens. Journal of Applied Bacteriology 46:579–584
    [Google Scholar]
  3. Eickhoff T. C., Steinhauer B. W., Finland M. 1966; The Klebsiella-Enterobacter-Serratia Division. Biochemical and serologic characteristics and susceptibility to antibiotics Annals of Internal Medicine; 65:1163–1179
    [Google Scholar]
  4. Finney D. J. 1964; Statistical method in biological assay. 2nd edn Hafner Publishing Company New York: p 524
    [Google Scholar]
  5. Foster W. D., Bragg J. 1962; Biochemical classification of Klebsiella correlated with the severity of the associated disease. Journal of Clinical Pathology 15:478–481
    [Google Scholar]
  6. Friedländer C. 1882; Ueber die Schizomyceten bei der acuten fibrosen Pneumonie. Virchows Archive fur Pathologische Anatomie und Physiologie 87:319–324
    [Google Scholar]
  7. Henriksen S. D. 1954; Studies on the Klebsiella group (Kauffman); serotypes of a collection of strains from human sources and from water. Acta Pathologica et Microbiologica Scandinavia 34:249–258
    [Google Scholar]
  8. Hyde L., Hyde B. 1943; Primary Friedlander pneumonia. American Journal of Medical Sciences 205:660–675
    [Google Scholar]
  9. Julianelle L. A. 1926; A biological classification of encapsulatus pneumoniae (Friedländer’s bacillus). Journal of Experimental Medicine 44:113–128
    [Google Scholar]
  10. Julianelle L. A. 1941; The pneumonia of Friedländer’s bacillus. Annals of Internal Medicine 15:190–206
    [Google Scholar]
  11. Maskell J. P. 1981; The pathogenicity of Bacteroides fragilis and related species estimated by intracutaneous infection in the guinea-pig. Journal of Medical Microbiology 14:131–140
    [Google Scholar]
  12. Miles A. A., Miles E. M., Burke J. 1957; The value and duration of defence reactions of the skin to the primary lodgement of bacteria. British Journal of Experimental Pathology 38:79–96
    [Google Scholar]
  13. Miles A. A., Pillow J., Khimji P. L. 1976; The action of iron on local Klebsiella infection of the skin of the guinea-pig and its relation to the decisive period in primary infective lesions. British Journal of Experimental Pathology 57:217–242
    [Google Scholar]
  14. Montgomerie J. Z. 1979; Epidemiology of Klebsiella and hospital-associated infections. Reviews of Infectious Diseases 1:7363–75
    [Google Scholar]
  15. Orskov I. 1955; Serological investigations in the Klebsiella group. 2. Occurrence of Klebsiella in sputa. Acta Pathologica et Microbiologica Scandinavia 36:454–460
    [Google Scholar]
  16. Orskov I. 1974 Klebsiella In Buchanan R. E., Gibbon S. W. E. (eds) Bergey’s Manual of Determinative Bacteriology. 8th edn The Williams and Wilkins Company; Baltimore: pp 321–324
    [Google Scholar]
  17. Perlman E., Bullowa J. G. M. 1941; Primary bacillus Friedlander (Klebsiella pneumoniae) pneumonia; therapy of B Friedlander pneumonia. Archives of Internal Medicine 67:907–920
    [Google Scholar]
  18. Riser E., Noonme P. 1981; Klebsiella capsular type versus site of isolation. Journal of Clinical Pathology 34:552–555
    [Google Scholar]
  19. Smith S. M., Digori J. T., Eng R. H. K. 1982; Epidemiology of Klebsiella antibiotic resistance and serotypes. Journal of Clinical Microbiology 16:868–873
    [Google Scholar]
  20. Solomon S. 1937; Primary Friedlander pneumonia: report of 32 cases. Journal of American Medical Association 108:937–947
    [Google Scholar]
  21. Steinhauer B. W., Eickhoff T. C., Kislak J. W., Finland M. 1966; The Klebsiella-Enterobacter-Serratia Division. Clinical and epidemiologic characteristics Annals of Internal Medicine; 65:1180–1194
    [Google Scholar]
  22. Tillotson J. R., Finland M. 1969; Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia. Journal of Infectious Diseases 119:597–624
    [Google Scholar]
  23. Wilson G. S., Miles A. A. 1975; Topley and Wilson’s Principles of bacteriology, virology and immunity. 6th edn Edward Arnold Publishers Ltd; London: p 875
    [Google Scholar]
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