1887

Abstract

SUMMARY

Intraperitoneal injection of ss. into HAM/1CR mice was lethal, but viable counts of bacteria from whole body homogenates, organs and blood indicated that death was not due to sustained bacterial multiplication. Heat-killed organisms (5 x 10 cfu) injected into 7-day-old mice caused death within 24 h and this was shown to be due to endotoxin. Both ferric iron and heterologous lipopolysaccharide enhanced virulence; the LD50 was lowered from 1.8 × 10 cfu to 2.7 × 10 cfu when both were used. Three-day-old or adult animals survived challenge with without clinical symptoms when challenged orally or by intravenous or intraperitoneal routes.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-18-1-27
1984-08-01
2024-05-02
Loading full text...

Full text loading...

/deliver/fulltext/jmm/18/1/medmicro-18-1-27.html?itemId=/content/journal/jmm/10.1099/00222615-18-1-27&mimeType=html&fmt=ahah

References

  1. Argyris B. F. 1968; Role of macrophages in immunological maturation. Journal of Experimental Medicine 128:459–467
    [Google Scholar]
  2. Baker P. J., Wilson J. B. 1965; Hypoferremia in mice and its application to the bioassay of endotoxin. Journal of Bacteriology 90:903–910
    [Google Scholar]
  3. Benacerraf B., Halpern B. N., Biozzi G., Benos S. A. 1954; Quantitative study of the granulopectic activity of the reticulo-endothelial system. III. The effect of cortisone and nitrogen mustard on the regenerative capacity of the R.E.S. after saturation with carbon. British Journal of Experimental Pathology 35:97–106
    [Google Scholar]
  4. Blaser M. J., Duncan D. J., Warren G. H., Wang W.-L. L. 1983; Experimental Campylobacter jejuni infection of adult mice. Infection and Immunity 39:908–916
    [Google Scholar]
  5. Boyd W. C. 1956; Fundamentals of immunology. Interscience Pub. Inc New York:
    [Google Scholar]
  6. Bullen J. J. 1981; The significance of iron in infection. Reviews of Infectious Diseases 3:1127–1138
    [Google Scholar]
  7. Bullen J. J., Rogers H. J. 1969; Bacterial iron metabolism and immunity to Pasteurella septica and Escherichia coli. Nature 224:380–382
    [Google Scholar]
  8. Bullen J. J., Rogers H. J., Griffiths E. 1978; Role of iron in bacterial infection. Current Topics in Microbiology and Immunology 80:1–35
    [Google Scholar]
  9. Butzler J.-P., DeKeyser P., Detrain M., Dehaen F. 1973; Related vibrios in stools. Journal of Pediatrics 82:493–495
    [Google Scholar]
  10. Butzler J.-P., Skirrow M. B. 1979; Campylobacter enteritis. Clinical Gastroenterology 8:737–765
    [Google Scholar]
  11. Cartwright G. E., Lauritsen M. A., Humphreys S., Jones P. J., Merrill I. M., Wintrobe M. M. 1946; The anemia of infection. II. The experimental production of hypoferremia and anemia in dogs. Journal of Clinical Investigation 25:81–86
    [Google Scholar]
  12. Field L. H., Underwood J. L., Berry L. J. 1982; Colonization of the digestive tract of adult mice with Campylobacter fetus ssp. jejuni. Abstracts of the Meeting of the American Society of Microbiology42
    [Google Scholar]
  13. Guerrant R. L., Lahita R. G., Winn W. C., Roberts R. B. 1978; Campylobacteriosis in man-pathogenic mechanisms and review of 91 bloodstream infections. American Journal of Medicine 65:584–592
    [Google Scholar]
  14. Hallett A. F., Botha P. L., Logan A. 1977; Isolation of Campylobacter fetus from recent cases of human vibriosis. Journal of Hygiene 79:381–389
    [Google Scholar]
  15. Jackson J. F., Hinton P., Allison F. 1960; Human vibriosis. Report of a patient with relapsing febrile illness due to Vibrio fetus. American Journal of Medicine 28:986–994
    [Google Scholar]
  16. Jones F. S., Orcutt M., Little R. B. 1931; Vibrios (Vibrio jejuni sp.) associated with intestinal disorders of cows and calves. Journal of Experimental Medicine 53:853–863
    [Google Scholar]
  17. Kampschmidt R. F., Upchurch H. F. 1962; Effects of bacteria endotoxin on plasma iron. Proceedings of the Society for Experimental Biology and Medicine 110:191–193
    [Google Scholar]
  18. Kampschmidt R. F., Upchurch H. F. 1964; Effect of endotoxin upon total iron-binding capacity of the serum. Proceedings of the Society for Experimental Biology and Medicine 116:420–422
    [Google Scholar]
  19. Lambert M. E., Schofield P. F., Ironside A. G., Mandal B. K. 1979; Campylobacter colitis. British Medical Journal 1:857–859
    [Google Scholar]
  20. Levy A. J. 1946; A gastro-enteritis outbreak probably due to a bovine strain of Vibrio. Yale Journal of Biology and Medicine 18:243–258
    [Google Scholar]
  21. McKay S. E., Arbuthnott J. P. 1979; Age-related susceptibility of mice to staphylococcal infection. Journal of Medical Microbiology 12:99–106
    [Google Scholar]
  22. Mandel A. D., Ellison R. C. 1963; Acute dysentery syndrome caused by Vibrio fetus. Journal of the American Medical Association 185:536–538
    [Google Scholar]
  23. Manninen K. I., Prescott J. F., Dohoo I. R. 1982; Pathogenicity of Campylobacter jejuni isolates from animals and human. Infection and Immunity 38:46–52
    [Google Scholar]
  24. Middelkamp J. N., Wolf H. A. 1961; Infection due to a ‘related vibrio’. Journal of Pediatrics 59:318–321
    [Google Scholar]
  25. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood. Journal of Hygiene 38:732–749
    [Google Scholar]
  26. Morgan E. H. 1974; Transferrin and transferrin iron. In Jacobs A., Worwood M. (eds) Iron in biochemistry and medicine. Academic Press; London: pp 29–71
    [Google Scholar]
  27. Ng F. K. P. 1981; Studies on Campylobacter fetus subspecies jejuni. Ph.D. thesis University of Glasgow;
    [Google Scholar]
  28. Philip D. A., Tilton R. C. 1977; Campylobacter and Spirillum. In Seligson D. (ed) CRC Handbook Series in Clinical Laboratory Science;
    [Google Scholar]
  29. Prescott J. F., Karmali M. A. 1978; Attempts to transmit Campylobacter enteritis to dogs and cats. Canadian Medical Association Journal 119:1001–1002
    [Google Scholar]
  30. Robinson B. L. 1978; Infection of humans with Campylobacter fetus. Canadian Medical Association Journal 118:1087–1088
    [Google Scholar]
  31. Ruiz-Palacios G. M., Escamilla E., Torres N. 1981; Experimental Campylobacter diarrhea in chickens. Infection and Immunity 34:250–255
    [Google Scholar]
  32. Skirrow M. B. 1977; Campylobacter enteritis: a “new” disease. British Medical Journal 2:9–11
    [Google Scholar]
  33. Smibert R. M. 1978; The genus Campylobacter. Annual Review of Microbiology 32:673–709
    [Google Scholar]
  34. Van Snick J. L., Masson P. L., Heremans J. F. 1974; The involvement of lactoferrin in the hyposideremia of acute inflammation. Journal of Experimental Medicine 140:1068–1084
    [Google Scholar]
  35. Wheeler W. E., Borchers J. 1961; Vibrionic enteritis in infants. American Journal of Diseases of Children 101:60–66
    [Google Scholar]
  36. Wolcott G. H., Boyer P. D. 1948; A colorimetric method for the determination of citric acid in blood and plasma. Journal of Biological Chemistry 172:729–736
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-18-1-27
Loading
/content/journal/jmm/10.1099/00222615-18-1-27
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error