f Haemolysin And Enzyme Patterns Of Coagulase-Positive Staphylococci Isolated From Toxic Epidermal Necrolysis, Ritter'S Disease And Impetigo Contagiosa
- Authors: J. P. Arbuthnott*, C. G. Gemmell†, Janet Kent‡, A. Lyell
- First Published Online: 01 November 1969, Journal of Medical Microbiology 2: 479-487, doi: 10.1099/00222615-2-4-479
- Subject: Articles
- Issue Published:
Strains of Staphylococcus aureus isolated from toxic epidermal necrolysis and Ritter's disease (named collectively “ Ritter's type ” of TEN) and from extensive cases of impetigo contagiosa, in which the diagnosis of Ritter's type of TEN was considered seriously, were assigned to group E (extensive lesions) and were compared with strains of S. aureus isolated from unequivocal impetigo contagiosa (group L—localised lesions); 24 of the 26 isolates examined belonged to phage-group II.
Strains from groups E and L were generally similar in their patterns of proteolytic activity, low incidence of positive egg-yolk reaction, possession of lipase and production of hyaluronidase. The difference lay in the many isolates in group E that produced a low-titre lysin active against rabbit red cells that was not α-haemolysin. The average titre of lysin active against rabbit erythrocytes in group E was 355 MHD per mi and in group L 1008 MHD per mi. Reasons are given for supposing that this low titre rabbit cell lysin is identical with staphylococcal δ-toxin. It is suggested that δ-toxin may play a part in the pathogenesis of Ritter's type of TEN and extensive impetigo.
Completed part of this work while holding a Carnegie Vacation Scholarship.
Nuffield Foundation Research Fellow.
Alan Johnston, Lawrence and Moseley Research Fellow of The Royal Society.
©E & S LIVINGSTONE, LTD. 1969 | Published by the Microbiology Society
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