f Cross-reactions in cell-mediated immunity to Salmonella causing enteric fever
- Authors: Hemlatta Tiwari, R. S. Kamat
- Correspondence and requests for offprints should be sent to Dr R.S. Kamat.
- First Published Online: 01 May 1986, Journal of Medical Microbiology 21: 233-237, doi: 10.1099/00222615-21-3-233
- Subject: Articles
- Issue Published:
Cross-reactivity in a delayed-type hypersensitivity (DH) response was studied in mice immunised with live Salmonella typhi, S. paratyphi A and S. paratyphi B. Extensive cross-reactions outside the serogroup limits were observed. The ability of DH cross-reacting and non-cross-reacting sonicates to generate activated macrophages was studied in mice immunised 3 months earlier with S. paratyphi B. Whereas DH cross-reacting S. poona sonicate generated activated macrophages the non-cross-reacting S. typhi sonicate did not. To determine whether infections due to diarrhoea-causing salmonellae generated cross-reactive cell-mediated immune responses against enteric fever-causing organisms, similar reverse experiments were performed in mice immunised with S. enteritidis. S. paratyphi A sonicate generated both effector responses, i.e., DH and activated macrophages.
Article metrics loading...
Full text loading...
Author and Article Information
/content/journal/jmm/10.1099/00222615-21-3-233dcterms_title,dcterms_subject,pub_serialTitlepub_serialIdent:journal/jmm AND -contentType:BlogPost104
/content/journal/jmm/10.1099/00222615-21-3-233dcterms_title,dcterms_subject-pub_serialIdent:journal/jmm AND -contentType:BlogPost104
Figure data loading....