@article{mbs:/content/journal/jmm/10.1099/00222615-21-3-233, author = "Tiwari, Hemlatta and Kamat, R. S.", title = "Cross-reactions in cell-mediated immunity to Salmonella causing enteric fever", journal= "Journal of Medical Microbiology", year = "1986", volume = "21", number = "3", pages = "233-237", doi = "https://doi.org/10.1099/00222615-21-3-233", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-21-3-233", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary Cross-reactivity in a delayed-type hypersensitivity (DH) response was studied in mice immunised with live Salmonella typhi, S. paratyphi A and S. paratyphi B. Extensive cross-reactions outside the serogroup limits were observed. The ability of DH cross-reacting and non-cross-reacting sonicates to generate activated macrophages was studied in mice immunised 3 months earlier with S. paratyphi B. Whereas DH cross-reacting S. poona sonicate generated activated macrophages the non-cross-reacting S. typhi sonicate did not. To determine whether infections due to diarrhoea-causing salmonellae generated cross-reactive cell-mediated immune responses against enteric fever-causing organisms, similar reverse experiments were performed in mice immunised with S. enteritidis. S. paratyphi A sonicate generated both effector responses, i.e., DH and activated macrophages.", }