1887

Abstract

Summary

Under uniform experimental conditions, different degrees of selective attachment of and to epithelial cells of the labium majus, the labium minus, and the vagina were compared and contrasted with those found in studies with cells of the buccal and nasal mucosa and forearm skin by a novel analysis of adherence density. For both micro-organisms, the larger, rougher cells of the labium majus gave the highest adherence scores matched only by the interaction of with fully keratinised nasal epithelial cells. Increasing acidity to H 3.5 enhanced microbial adherence to vaginal cells. Menstruation also influenced attachment; highest densities were reached between the third and fourth weeks of the cycle. Autogenous ribitol teichoic acid was found to block the attachment of to labium majus and labium minus cells by 76% and 81% respectively, and to vaginal cells by 66%. Adherence is considered to be an important attribute of vulvar ecology and may be a determinant of infectious disease.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-23-1-75
1987-02-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jmm/23/1/medmicro-23-1-75.html?itemId=/content/journal/jmm/10.1099/00222615-23-1-75&mimeType=html&fmt=ahah

References

  1. Aly R., Britz M. B., Maibach H. I. 1979; Quantitative microbiology of the human vulva. British Journal of Dermatology 101:445–448
    [Google Scholar]
  2. Aly R., Shinefield H. R., Litz C., Maibach H. I. 1980; Role of teichoic acid in the binding of Staphylococcus aureus to nasal epithelial cells. Journal of Infectious Diseases 141:463–465
    [Google Scholar]
  3. Aly R., Shinefield H. R., Strauss W. G., Maibach H. I. 1977; Bacterial adherence to nasal mucosal cells. Infection and Immunity 17:546–549
    [Google Scholar]
  4. Bartlett J. G., Onderdonk A. B., Drude E., Goldstein C., Anderka M., Alpert S., McCormack W. M. 1977; Quantitative bacteriology of the vaginal flora. Journal of Infectious Diseases 136:271–277
    [Google Scholar]
  5. Beachey E. H. 1980 Bacterial adherence, receptors and recognition Series B. vol 6 Chapman and Hall; London:
    [Google Scholar]
  6. Beachey E. H., Simpson W. A., Ofek I., Hasty D. L., Dale J. B., Whitnack E. 1983; Attachment of Streptococcus pyogenes to mammalian cells. Reviews of Infectious Diseases 5: Suppl 4S670–S677
    [Google Scholar]
  7. Bibel D. J., Aly R., Bayles C., Strauss W. G., Shinefield H. R., Maibach H. I. 1983; Competitive adherence as a mechanism of bacterial interference. Canadian Journal of Microbiology 29:700–703
    [Google Scholar]
  8. Bibel D. J., Aly R., Shinefield H. R., Maibach H. I., Strauss W. G. 1982; Importance of the keratinized epithelial cell in bacterial adherence. Journal of Investigative Dermatology 79:250–253
    [Google Scholar]
  9. Botta G. A. 1979; Hormonal and type-dependent adhesion of group B streptococci to human vaginal cells. Infection and Immunity 25:1084–1086
    [Google Scholar]
  10. Freter R., Jones G. W. 1983; Models for studying the role of bacterial attachment in virulence and pathogenesis. Reviews of Infectious Diseases 5: Suppl 4S647–S658
    [Google Scholar]
  11. Friedrich E. G. 1976 Vulvar disease W B Saunders; Philadelphia: p 8
    [Google Scholar]
  12. Galask R. P., Larsen B., Ohm M. J. 1976; Vaginal flora and its role in disease entities. Clinical Obstetrics and Gynecology 19:61–81
    [Google Scholar]
  13. Gibbons R. J., VanHoute J. 1975; Bacterial adherence in oral microbial ecology. Annual Review of Microbiology 29:19–44
    [Google Scholar]
  14. King R. D., Lee J. C., Morris A. L. 1980; Adherence of Candida albicans and other Candida species to mucosal epithelial cells. Infection and Immunity 27:667–674
    [Google Scholar]
  15. Linnemann C. C. 1982; The epidemiology of genital ■colonization with Staphylococcus aureus. Annals of Internal Medicine 96:940–944
    [Google Scholar]
  16. Mårdh P.-A. M. L. 1976; Adherence of bacteria to vaginal epithelial cells. Infection and Immunity 13:661–666
    [Google Scholar]
  17. Ofek I., Beachey E. H. 1980; General concepts and principles of bacterial adherence in animals and man. In Beachey E. H. (ed) Bacterial adherence, receptors and recognition Series B vol 6 Chapman and Hall; London: pp 1–29
    [Google Scholar]
  18. Rosenstein I. J., Grady D., Miller J. M. T., Brumfitt W. 1985; Relationship between adhesion of Escherichia coli to uro-epithelial cells and the pathogenesis of urinary infection: problems in methodology and analysis. Journal of Medical Microbiology 20:335–344
    [Google Scholar]
  19. Sobel J. D., Myers P. G., Kaye D., Levison M. E. 1981a; Adherence of Candida albicans to human vaginal and buccal epithelial cells. Journal of Infectious Diseases 143:76–82
    [Google Scholar]
  20. Sobel J. D., Schneider J., Kaye D., Levison M. E. 1981; Adherence of bacteria to vaginal epithelial cells at various times in the menstrual cycle. Infection and Immunity 32:194–197
    [Google Scholar]
  21. Williamson P., Kligman A. M. 1965; A new method for the quantitative investigation of cutaneous bacteria. Journal of Investigative Dermatology 45:498–503
    [Google Scholar]
  22. Woods D. E., Straus D. C., Johanson W. G., Berry V. K., Bass J. A. 1980; Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells. Infection and Immunity 29:1146–1151
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-23-1-75
Loading
/content/journal/jmm/10.1099/00222615-23-1-75
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error