The effects of Clostridium difficile crude toxins and purified toxin A on stripped rabbit ileal mucosa in Ussing chambers

References

1. Banno Y., Kobayashi T., Kono H., Watanabe K., Ueno K., Nozawa Y. 1984; Biochemical characterization and biologic actions of two toxins (D-l and D-2) from Clostridium difficile. Reviews of Infectious Diseases 6: Suppl SI1–S20
   [Google Scholar]
2. Bartlett J. G., Moon N., Chang T. W., Taylor N. S., Onderdonk A. B. 1978; Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastroenterology 75:778–782
   [Google Scholar]
3. Donowitz M., Keusch G. T., Binder H. J. 1975; Effect of Shigella enterotoxin on electrolyte transport in rabbit ileum. Gastro enterology 69:1230–1237
   [Google Scholar]
4. Field M., Fromm D., Awqati Q., Greenough W. B. 1972; Effect of cholera enterotoxin on ion transport across isolated ileal mucosa. Journal of Clinical Investigation 51:796–804
   [Google Scholar]
5. Frizzell R. A., Schultz S. G. 1972; Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differences. Journal of General Physiology 59:318–346
   [Google Scholar]
6. George R. H. 1978; Identification of Clostridium difficile as a cause of pseudomembranous colitis. British Medical Journal 1:695
   [Google Scholar]
7. Hughes S., Warhurst G., Turnberg L. A., Higgs N. B., Giugliano L. G., Drasar B. S. 1983; Clostridium difficile toxin-induced intestinal secretion in rabbit ileum invitro. Gut 24:94–98
   [Google Scholar]
8. Isaacs Corbett C. L., Riley A. K., Hawker P. C., Turnberg L. A. 1976; In-vitro behaviour of human intestinal mucosa. The influence of acetylcholine on ion transport. Journal of Clinical Investigation 58:535–542
   [Google Scholar]
9. Ketley J. M., Mitchell T. J., Candy D. C. A., Burdon D. W., Stephen J. 1987; The effects of Clostridium difficile crude toxins and toxin A on ileal and colonic loops in immune and nonimmune rabbits. Journal of Medical Microbiology 23:199–204
   [Google Scholar]
10. Lonnroth I., Lange S. 1983; Toxin A of Clostridium difficile: production, purification and effect in mouse intestine. Acta Pathologica et Microbiologica Scandinavica B91:395–400
    [Google Scholar]
11. Lyerly D. M., Saum K. E., MacDonald D. K., Wilkins T. D. 1985; Effects of Clostridium difficile toxins given intragastrically to animals. Infection and Immunity 47:349–352
    [Google Scholar]
12. Lyerly D. M., Wilkins T. D. 1986; Commercial latex test for Clostridium difficile Toxin A does not detect toxin A. Journal of Clinical Microbiology 23:622–623
    [Google Scholar]
13. McDonel J. L. 1974; In Vivo effects of Clostridium perfringens enteropathogenic factors on the rat ileum. Infection and Immunity 10:1156–1162
    [Google Scholar]
14. McDonel J. L., Asano T. 1975; Analysis of unidirectional fluxes of sodium during diarrhea induced by Clostridium perfringens enterotoxin in the rat terminal ileum. Infection and Immunity 11:526–529
    [Google Scholar]
15. Mitchell T. J. 1986; The effect of toxin A and toxin B of Clostridium difficile on rabbit ileum and colon. Gut 27:78–85
    [Google Scholar]
16. Mitchell T. J., Ketley J. M., Burdon D. W., Candy D. C. A., Stephen J. 1987a; The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and invitro and in McCoy cells invitro. Journal of Medical Microbiology 23:199–204
    [Google Scholar]
17. Mitchell T. J., Ketley J. M., Burdon D. W., Candy D. C. A., Stephen J. 1987b; Biological mode of action of Clostridium difficile toxin A: a novel enterotoxin. Journal of Medical Microbiology 23:199–204
    [Google Scholar]
18. Mogg G. A. G. 1979; Antibiotic-associated colitis—a review of 66 cases. British Journal of Surgery 66:738–742
    [Google Scholar]
19. Redmond S. C., Ketley J. M., Mitchell T. J., Stephen J., Burdon D. W., Candy D. C. A. 1985; Detection of Clostridiumdifficile enterotoxin. In Collins C. H., Grange J. M. (eds) Isolation and identification of micro-organisms of medical and veterinary importance (Society of Applied Bacteriology, Symposium Series no. 21) Academic Press; London: pp 237–250
    [Google Scholar]
20. Schultz S. G., Zalusky R. 1964; Ion transport in isolated rabbit ileum. I. Short circuit current and Na fluxes. Journal of General Physiology 47:567–584
    [Google Scholar]
21. Stephen J. 1984; Clostridium difficile enterotoxin (toxin A): new results. Biochemical Society Transactions 12:194–195
    [Google Scholar]
22. Taylor N. S., Thome G. M., Bartlett J. G. 1981; Comparison of two toxins produced by Clostridium difficile. Infection and Immunity 34:1036–1043
    [Google Scholar]
23. Vesely D. L., Straub K. D., Nolan C. M., Rolfe R. D., Finegold S. M., Monson T. P. 1981; Purified Clostridium difficile cytotoxin stimulates guanylate cyclase activity and inhibits adenylate cyclase activity. Infection and Immunity 33:285–291
    [Google Scholar]
24. Vesely D. L., Sullivan N. M., Straub K. D., Monson T. P., Wilkins T. D. 1983; Clostridium difficile toxin A and toxin B both enhance guanylate cyclase activity. Clinical Research 31:378A
    [Google Scholar]