@article{mbs:/content/journal/jmm/10.1099/00222615-3-3-529, author = "Nicholls, M. W. N.", title = "Polymyxin Sensitivity Of Candida Tropicalis", journal= "Journal of Medical Microbiology", year = "1970", volume = "3", number = "3", pages = "529-538", doi = "https://doi.org/10.1099/00222615-3-3-529", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-3-3-529", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "SUMMARY Polymyxin B, polymyxin E, and colistin sulphomethate sodium are fungicidal in vitro for Candida tropicalis. Four hundred random isolates of Candida from two hospital laboratories were tested for sensitivity to colistin: 25 (6.2 per cent.) were sensitive, and 22 of these were C. tropicalis. One hundred and twelve isolates of eight species of Candida were screened for sensitivity to colistin and, of the 14 that were sensitive, 12 were C. tropicalis. Polymyxins B and E liberate intracellular material from C. tropicalis, which suggests that the drug acts on the yeast cell-membrane. Colistin sulphomethate was successfully used to treat a urinary-tract infection with this species of Candida. The potential therapeutic value of polymyxins for C. tropicalis infections is discussed.", }