f Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori
- Authors: K. A. Eaton, D. R. Morgan, S. Krakowka
- J. Med. Microbiol., August 1992 37: 123-127, doi: 10.1099/00222615-37-2-123
- Subject: Article
- Published Online:
Non-motile variants of Helicobacter pylori (strain 26695) occurred with a frequency of 1·6 (SD 0·4) × 10-4 variants/cell/division cycle, and reversion to the motile form occurred with a frequency of < 10-7 variants/cell/division cycle. The two forms remained > 90% pure for up to 50 cell divisions and differed only in the presence or absence of motility and flagella. Bacteria were recovered from nine of 10 gnotobiotic piglets inoculated orally with motile H. pylori, but from only two of eight inoculated with the non-motile variant. The motile form survived for 21 days in infected piglets, but the non-motile variant survived for only 6 days. Bacteria recovered from piglets inoculated with the non-motile variant were non-motile. These data support the hypothesis that motility is a colonisation factor for H. pylori.
© 1992 The Pathological Society of Great Britain and Ireland | Published by the Microbiology Society
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