f Treatment of experimental infections of mice with bacteriophages
- By J. S. SOOTHILL*
- *Correspondence should be sent to Dr J. S. Soothill, The Burns Research Group, Birmingham Accident Hospital, Bath Row, Birmingham B15 1NA.
- J. Med. Microbiol., October 1992 37: 258-261, doi: 10.1099/00222615-37-4-258
- Subject: Article
- Published Online:
Bacteriophages for Acinetobacter baumanii, Pseudomonas aeruginosa and Staphylococcus aureus were tested in experimental infections of mice to investigate their potential for the treatment of infections of man. As few as 102 particles of an acinetobacter phage protected mice against 5 LD50 (1 × 108) of a virulent strain of A. baumanii, and phage was demonstrated to have multiplied in the mice. A pseudomonas phage protected mice against 5 LD50 of a virulent strain of P. aeruginosa, with a PD50 of 1.2 × 107 particles. A staphylococcal phage failed to protect mice infected with a strain of S. aureus. These studies support the view that bacteriophages could be useful in the treatment of human infections caused by antibiotic-resistant strains of bacteria.
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