1887

Abstract

Summary

Probes constructed from a 4.05-kb R1 digest fragment of a mupirocin resistance plasmid and a 751-bp internal part of this fragment hybridised with DNA from all of 36 independent high-level mupirocin-resistant staphylococci tested from seven centres; most were . In most instances the probes detected an R1 digest fragment of approximately 4 kb. Probes did not hybridise to DNA from low-level resistant strains, nor from strains sensitive to mupirocin.

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/content/journal/jmm/10.1099/00222615-39-6-446
1993-12-01
2024-04-27
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References

  1. Rahman M, Noble WC, Cookson B. Mupirocin-resistant Staphylococcus aureus. Lancet 1987; 2:387
    [Google Scholar]
  2. Rahman M, Noble WC, Cookson B. Transmissible mupirocin resistance in Staphylococcus aureus. Epidemiol Infect 1989; 102:261–270
    [Google Scholar]
  3. Gilbart J, Perry CR, Slocombe B. High level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases. Antimicrob Agents Chemother 1993; 37:32–38
    [Google Scholar]
  4. Rahman M, Connolly S, Noble WC, Cookson B, Phillips I. Diversity of staphylococci exhibiting high level resistance to mupirocin. J Med Microbiol 1990; 33:97–100
    [Google Scholar]
  5. Dyke KGH, Curnock SP, Golding M, Noble WC. Cloning of the gene conferring resistance to mupirocin in Staphylococcus aureus. FEMS Microbiol Lett 1991; 61:195–198
    [Google Scholar]
  6. Connolly S, Noble WC, Phillips I. Mupirocin resistance in coagulase-negative staphylococci. J Med Microbiol 1993; 39:450–453
    [Google Scholar]
  7. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning—A laboratory manual, 2nd edn.. Cold Spring Harbor NY: Cold Spring Harbor Laboratory Press; 198938–41
    [Google Scholar]
  8. Casewell M, Hill RLR. The laboratory assessment of the antistaphylococcal activity of mupirocin. In: Mupirocin: a novel topical antibiotic Royal Society of Medicine; 198457–64
    [Google Scholar]
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