Detection of antibodies against phenolic glycolipid-1 (PGL-1), 35-kDa and 30-40-kDa components of Mycrobacterium leprae in the cerebrospinal fluid of leprosy patients
Patil, Shripad A. and Katoch, Kiran and Ramu, G. and Sengupta, U.,, 43, 115-119 (1995),
doi = https://doi.org/10.1099/00222615-43-2-115,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Summary The involvement of the central nervous system (CNS) in lepromatous leprosy (LL) patients was investigated; 33 patients were examined clinically in detail and upper motor neuron involvement was observed in eight and lower motor neuron in three of these patients. Anti-Mycobacterium leprae antibodies could be detected in the CSF by PGL-1 enzyme-linked immunosorbent assay (ELISA) and monoclonal antibody (MAb) based competitive assays against defined epitopes on the 35-kDa protein and 30–40-kDa polysaccharide (lipo-arabinomannan) antigens with MAbs ML04 and ML34, respectively. Antibodies against PGL-1 and 35-kDa protein were observed in more subjects than antibodies against the 30-40-kDa antigen. Some correlation was observed between the upper motor neuron signs and antibody positivity for 35-kDa and PGL-1 antigens in the CSF of these patients.,
language=,
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