1887

Abstract

Summary

Penicillin-resistant strains isolated in different parts of Germany between 1982 and 1992 were compared with penicillin-resistant isolates, mainly of serogroups 6, 9, 14, 19 and 23, from other European countries. The main clones were recognised by their serotypes, antibiotic resistance patterns and penicillin-binding protein properties, and this typing was confirmed by multi-locus enzyme electrophoresis for a sample of 43 selected isolates. Eleven of the 14 resistant German isolates could be assigned to five genotypes isolated also in other countries. These included representatives of two distinct serotype 23F lineages predominant in Spain and France; a cluster of three serotype 6B isolates identical to clones in Spain, France, Finland and Hungary; and a serotype 9V clone of a type prevalent in Spain and now also in France. Serotype 19A clones of the type found in Hungary were not collected in Germany. The data suggest that two 23F lineages, represented by seven isolates from different locations, have become disseminated in Germany. Several resistant types found in the former West Germany resembled those found elsewhere in Western Europe whereas those from East Germany were distinct or, in one case, resembled a clone from Hungary. These data may reflect pre-unification travel patterns.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-43-5-377
1995-11-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/43/5/medmicro-43-5-377.html?itemId=/content/journal/jmm/10.1099/00222615-43-5-377&mimeType=html&fmt=ahah

References

  1. Appelbaum P. C. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis 1992; 15:77–83
    [Google Scholar]
  2. Klugman K. P. Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990; 3:171–196
    [Google Scholar]
  3. Fenoll A., Martin-Bourgon C., Munoz R., Vicioso D., Casal J. Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing systemic infections in Spain, 1979-1989. Rev Infect Dis 1991; 13:56–60
    [Google Scholar]
  4. Linares J., Paliares R., Alonso T. Trends in antimicrobial resistance of clinical isolates of Streptococcus pneumoniae in Bellvitge Hospital, Barcelona, Spain (1979–1990). Clin Infect Dis 1992; 15:99–105
    [Google Scholar]
  5. Latorre C., Juncosa T., Sanfeliu I. Antibiotic resistance and serotypes of 100 Streptococcus pneumoniae strains isolated in a children’s hospital in Barcelona, Spain. Antimicrob Agents Chemother 1985; 28:357–359
    [Google Scholar]
  6. Marton A. Pneumococcal antimicrobial resistance: the problem in Hungary. Clin Infect Dis 1992; 15:106–111
    [Google Scholar]
  7. Sibold C., Wang J., Henrichsen J., Hakenbeck R. Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents. Infect Immun 1992; 60:4119–4126
    [Google Scholar]
  8. Marton A., Gulyas M., Munoz R., Tomasz A. Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary. J Infect Dis 1991; 163:542–548
    [Google Scholar]
  9. Munoz R., Coffey T. J., Daniels M. Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis 1991; 164:302–306
    [Google Scholar]
  10. McDougal L. K., Facklam R., Reeves M. Analysis of multiply antimicrobial-resistant isolates of Streptococcus pneumoniae from the United States. Antimicrob Agents Chemother 1992; 36:2176–2184
    [Google Scholar]
  11. Soares S., Kristinsson K. G., Musser J. M., Tomasz A. Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s. J Infect Dis 1993; 168:158–163
    [Google Scholar]
  12. Hakenbeck R., Briese T., Ellerbrok H. Targets of β-lactams in Streptococcus pneumoniae. In Actor P., Daneo-Moore L., Higgins M., Salton M. R. J., Shockman G. D. (eds) Antibiotic inhibition of bacterial cell surface assembly and function Washington DC: American Society for Microbiology; 1988390–399
    [Google Scholar]
  13. Hakenbeck R., Briese T., Chalkley L. Antigenic variation of penicillin-binding proteins from penicillin-resistant clinical strains of Streptococcus pneumonia. J Infect Dis 1993; 164:313–319
    [Google Scholar]
  14. Reinert R. R., Lütticken R., Kaufhold A. Aktuelle Daten zur Antibiotikaempfindlichkeit von Streptococcus pneumoniae (Pneumokokken) Die Bedeutung von penicillinresistenten Isolaten. Med Klinik 1993; 88:357–361
    [Google Scholar]
  15. Reinert R. R., Queck A., Kaufhold A., Kresken M., Lütticken R. Antibiotic sensitivity of Streptococcus pneumoniae isolated from normally sterile body sites: first results of a multicenter study in Germany. Infection 1994; 22:113–114
    [Google Scholar]
  16. Lacks S., Hotchkiss R. D. A study of the genetic material determining an enzyme activity in pneumococcus. Biochim Biophys Acta 1960; 39:508–518
    [Google Scholar]
  17. Hakenbeck R., Briese T., Chalkley L. Variability of penicillin-binding proteins from penicillin-sensitive Streptococcus pneumoniae. J Infect Dis 1993; 164:307–312
    [Google Scholar]
  18. Selander R. K., Caugant D. A., Ochman H., Musser J. M., Gilmore M. N., Whittam T. S. Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol 1986; 51:873–884
    [Google Scholar]
  19. Sneath P. H. A., Sokal R. R. Numerical Taxonomy. San Francisco: W. H. Freeman and Co.; 1973
    [Google Scholar]
  20. Geslin P., Frémaux A., Sissia G. Epidémiologie de la résistance de Streptococcus pneumoniae aux beta-lactamines en France et dans le monde. In Carbon C., Chastang C., Decazes J.-M. (eds) Infections a pneumocoques de sensibilité diminuée aux bêta-lactamines Paris: Springer-Verlag; 199355–71
    [Google Scholar]
  21. Munoz R., Musser J. M., Crain M. Geographic distribution of penicillin-resistant clones of Streptococcus pneumoniae: characterization by penicillin-binding protein profile, surface protein A typing, and multilocus enzyme analysis. Clin Infect Dis 1992; 15:112–118
    [Google Scholar]
  22. Versalovic J., Kapur V., Mason E. O. Penicillin-resistant Streptococcus pneumoniae strains recovered in Houston: identification and molecular characterization of multiple clones. J Infect Dis 1993; 167:850–856
    [Google Scholar]
  23. Jabes D., Nachman S., Tomasz A. Penicillin-binding protein families: evidence for the clonal nature of penicillin resistance in clinical isolates of pneumococci. J Infect Dis 1989; 159:16–25
    [Google Scholar]
  24. Hakenbeck R., Reichman P., Sibold C. Evolution and spread of β-lactam resistant Streptococcus pneumoniae. Klin Labor 1994; 40:230–235
    [Google Scholar]
  25. Gasc A.-M., Geslin P., Sicard A.-M. Relatedness of penicillin-resistant Streptococcus pneumoniae serogroup 9 strains from France and Spain. Microbiology 1995; 141:623–627
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-43-5-377
Loading
/content/journal/jmm/10.1099/00222615-43-5-377
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error