1887

Abstract

A virulent variant of the normally avirulent Kunz strain of influenza virus was obtained by serial passage in mice, and the pathogenesis of the infections caused by the two strains was studied.

The virulence of the passaged variant did not appear to result from increased growth in lungs, from acquisition of resistance to non-specific inhibitors or from inadequate immunogenicity, but from its greater ability to replicate in alveolar cells.

The apparent adequacy of defence mechanisms to protect against mucosal infection but their failure to protect against infection of alveolar cells is discussed.

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/content/journal/jmm/10.1099/00222615-8-1-127
1975-02-01
2024-04-19
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References

  1. Blandford G., Cureton R. J. R., Heath R. B. 1971; Studies of the immune response in Sendai virus infection of mice. J. med. Microbiol 4:351
    [Google Scholar]
  2. Blandford G., Heath R. B. 1972; Studies on the immune response and pathogenesis of Sendai virus infection of mice. Ⅰ. The fate of viral antigens. Immunology 22:637
    [Google Scholar]
  3. Blandford G., Heath R. B. 1974; Studies on the immune response and pathogenesis of Sendai virus infection of mice. Ⅱ. The immunoglobulin class of plasma cells in the bronchial sub-mucosa. Immunology 26:667
    [Google Scholar]
  4. Briody B. A., Cassel W. A., Medill M. A. 1955; Adaptation of influenza virus to mice. 3. Development of resistance to jS inhibitor. J. Immunol 74:41
    [Google Scholar]
  5. Davenport F. M. 1954; The inequality of potential in influenza virus for adaptation to mice. J. Immun 72:485
    [Google Scholar]
  6. Hirst G. K. 1947; Studies on the mechanism of adaptation of influenza virus to mice. J. exp. Med 86:357
    [Google Scholar]
  7. Horsfal F. L. 1939; Neutralization of epidemic influenza virus. The linear relationship between the quantity of serum and the quantity of virus neutralized. J. exp. Med 70:209
    [Google Scholar]
  8. Ledinko N. 1956; An analysis of the process of adaptation of influenza virus B of recent human origin to the mouse lung. J. gen. Microbiol 15:47
    [Google Scholar]
  9. Reed L. J., Muench H. 1938; A simple method of estimating 50% end point. Am. J. Hyg 27:493
    [Google Scholar]
  10. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1968; The pathogenesis of Sendai virus infection in the mouse lung. J. med. Microbiol 1:89
    [Google Scholar]
  11. Robinson T. W. E., Cureton R. J. R., Heath R. B. 1969; The effect of cyclophosphamide on Sendai virus infection of mice. J. med. Microbiol 2:137
    [Google Scholar]
  12. Sugg J. Y. 1950; The relation of the concentration of unadapted and adapted influenza virus in the mouse lung to the death or survival of the infected host. J. Bad 60:489
    [Google Scholar]
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