1887

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Volume 64, Issue 11

Resistance to clarithromycin and genotypes in strains isolated in Sicily Free

Abstract

The resistance of strains to clarithromycin is increasing in several developed countries and their association with a genetic pattern circulation has been variously explained as related to different geographical areas. In this study we have reported: the prevalence of the resistance of , isolated in Sicily, to clarithromycin; the principal point of mutation associated with this resistance; and the more frequent association between resistance to clarithromycin and , the EPIYA motif, and the and genes. Resistance to clarithromycin was detected in 25 % of cases, the main genetic mutation involved being A2143G. The gene was present in 48 % of cases and the distribution of the EPIYA motif was: ABC in 35 cases; ABCC in 8 cases; ABCCC in 2 cases; ABC-ABCC in 2 cases; and ABC-ABCC-ABCCC in 1 case. Regarding the allele, an combination was detected in 35 % of cases, in 12 %, in 12 %, in 40 %, and a double mosaic in 1 % of cases. The status of the gene was ‘off’ in 45 % of cases and ‘on’ in 55 %. Resistance to clarithromycin was found to be high in Sicily, but no correlation was found among resistance to clarithromycin, the gene and status; a higher correlation was observed between resistant strains and -negative strains.

  • Received:
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© 2015 The Authors
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2015-11-01
2024-04-19
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Resistance to clarithromycin and genotypes in Helicobacter pylori strains isolated in Sicily
J. Med. Microbiol. 64, 1408 (2015); https://doi.org/10.1099/jmm.0.000163
/content/journal/jmm/10.1099/jmm.0.000163
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