1887

Abstract

is an important opportunistic bacterial pathogen responsible for serious infections in hospitalized patients. From a total of 78 consecutive non-repetitive spp. isolates from patients with blood infections, 61 were carbapenem resistant, which were positive for (96.7 %), (77 %), (8.1 %) and genes (32.8 %) by multiplex PCR. The isolates were identified as ( = 59) and ( = 2). Also, we found a case of , causing bacteraemia, that possessed the IMP gene. High levels of resistance were observed to fluoroquinolones, aminoglycosides, tigecycline and to the beta-lactam antibiotics, including piperacillin/tazobactam and ampicillin/sulbactam. IS was present in 96.7 % of all complex (Acb) isolates. Also, 33 (54.1 %) and 23 (37.7 %) isolates harboured IS upstream of and genes, respectively, though this was not observed in isolates. No relationship was observed between the presence of IS upstream of oxacillinase genes and the level of carbapenem resistance in all Acb isolates. Only two genes encoding metallo-beta-lactamase (VIM, SPM) were detected in all Acb isolates. This suggests that carbapenem resistance in blood-isolate Acb is mostly due to the presence of acquired carbapenemases. This is the first report from Iran on the identification of isolates that possess multiple oxacillinase genes and lack upstream IS

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2016-03-01
2024-03-29
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