In vitro activities of tedizolid compared with other antibiotics against Gram-positive pathogens associated with hospital-acquired pneumonia, skin and soft tissue infection and bloodstream infection collected from 26 hospitals in China
Li, Shuguang and Guo, Yu and Zhao, Chunjiang and Chen, Hongbin and Hu, Bijie and Chu, Yunzhuo and Zhang, Zhijie and Hu, Yunjian and Liu, Zhiyong and Du, Yan and Gui, Qiaodi and Ji, Ping and Zeng, Ji and Cao, Bin and Fu, Quan and Zhang, Rong and Wang, Zhongxin and Zhuo, Chao and Feng, Xianju and Jia, Wei and Jin, Yan and Xu, Xuesong and Liao, Kang and Ni, Yuxing and Yu, Yunsong and Xu, Xiuli and Hu, Zhidong and Lei, Jin-E and Yang, Qing and Wang, Hui,, 65, 1215-1224 (2016),
doi = https://doi.org/10.1099/jmm.0.000347,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= To evaluate the in vitro antimicrobial activities of tedizolid, linezolid and other comparators against clinically significant Gram-positive cocci isolates from hospital-acquired pneumonia (HAP), skin and soft tissue infection (SSTI) and bloodstream infection (BSI), 2140 nonduplicate isolates (23.7 % isolated from HAP, 46.8 % from SSTI and 29.5 % from BSI) were consecutively collected in 26 hospitals in 17 cities across China during 2014. These pathogens included 632 methicillin-resistant Staphylococcus aureus, 867 methicillin-sensitive Staphylococcus aureus, 299 coagulase-negative Staphylococcus (CoNS), 104 Enterococcus faecalis, 99 Enterococcus faecium, 13 Streptococcus pneumoniae, 23 α-haemolytic Streptococcus and 103 β-haemolytic Streptococcus. MICs of routine clinical antibiotics were determined by broth microdilution method according to the Clinical and Laboratory Standards Institute guidelines 2015. Tedizolid, linezolid, vancomycin, daptomycin, teicoplanin and tigecycline showed high in vitro activity against Gram-positive pathogens (≥98.0 % susceptible), and tedizolid exhibited four- to eight fold greater activity than linezolid against the pathogens tested, with MIC90s of methicillin-resistant Staphylococcus aureus, α-haemolytic Streptococcus and β-haemolytic Streptococcus (0.25 vs 2 µg ml−1); methicillin-sensitive Staphylococcu s aureus, E. faecalis and E. faecium (0.5 vs 2 µg ml−1); methicillin-resistant CoNS and methicillin-sensitive CoNS (0.25 vs 1 µg ml−1); and Streptococcus pneumoniae (0.125 vs 0.5 µg ml−1). Tedizolid MIC90s associated with different infections did not show significant differences, and the drug exhibited excellent activity against surveyed Gram-positive pathogens associated with HAP, SSTI and BSI, including linezolid-nonsusceptible strains. These data suggest that tedizolid could be an alternative to linezolid for the treatment of infections caused by Gram-positive organisms.,
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