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Volume 65, Issue 12

Modulation of intestinal barrier function to ameliorate infection in mice by oral administration of fermented milks produced with MTCC 5690 – a probiotic strain of Indian gut origin Free

Abstract

Probiotic MTCC 5690, a probiotic strain of Indian gut origin, and milk formulations produced with the same were explored in this study as biotherapeutics by evaluating their functional efficacy against infection in mice. The efficacy of milk formulations (fermented/unfermented) of MTCC 5690 for enhancement of intestinal barrier function was determined by monitoring the permeability and histopathology of the intestine. Infected mice fed with probiotic Dahi, fermented probiotic drink and sweetened fermented probiotic drink maintained the health and integrity of the intestinal epithelium as compared to those fed with PBS, milk, unfermented probiotic milk and Dahi. Our relative expression data revealed that the changes caused by MTCC 5690 in intestinal barrier function components were established through modulation of the key regulatory receptors Toll-like receptor 2 and Toll-like receptor 4. The results suggest that fermented milks of MTCC 5690 could enhance the defences of the intestinal barrier in enteric infection condition and, therefore, can be explored as a dietary-based strategy to reduce infection in the human gut.

  • Received:
  • Accepted:
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Keyword(s): Intestinal barrier function , Intestinal permeability , Mouse model , MTCC 5690 based fermented milks and Salmonella
© 2016 The Authors
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2016-12-16
2024-04-18
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Modulation of intestinal barrier function to ameliorate Salmonella infection in mice by oral administration of fermented milks produced with Lactobacillus plantarum MTCC 5690 – a probiotic strain of Indian gut origin
J. Med. Microbiol. 65, 1482 (2016); https://doi.org/10.1099/jmm.0.000366
/content/journal/jmm/10.1099/jmm.0.000366
/content/journal/jmm/10.1099/jmm.0.000366
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