RT Journal Article SR Electronic(1) A1 Rokana, Namita A1 Singh, Rajbir A1 Mallappa, Rashmi Hogarehalli A1 Batish, Virender Kumar A1 Grover, SunitaYR 2016 T1 Modulation of intestinal barrier function to ameliorate Salmonella infection in mice by oral administration of fermented milks produced with Lactobacillus plantarum MTCC 5690 – a probiotic strain of Indian gut origin JF Journal of Medical Microbiology, VO 65 IS 12 SP 1482 OP 1493 DO https://doi.org/10.1099/jmm.0.000366 PB Microbiology Society, SN 1473-5644, AB Probiotic Lactobacillus plantarum MTCC 5690, a probiotic strain of Indian gut origin, and milk formulations produced with the same were explored in this study as biotherapeutics by evaluating their functional efficacy against Salmonella infection in mice. The efficacy of milk formulations (fermented/unfermented) of MTCC 5690 for enhancement of intestinal barrier function was determined by monitoring the permeability and histopathology of the intestine. Infected mice fed with probiotic Dahi, fermented probiotic drink and sweetened fermented probiotic drink maintained the health and integrity of the intestinal epithelium as compared to those fed with PBS, milk, unfermented probiotic milk and Dahi. Our relative expression data revealed that the changes caused by MTCC 5690 in intestinal barrier function components were established through modulation of the key regulatory receptors Toll-like receptor 2 and Toll-like receptor 4. The results suggest that fermented milks of MTCC 5690 could enhance the defences of the intestinal barrier in enteric infection condition and, therefore, can be explored as a dietary-based strategy to reduce Salmonella infection in the human gut., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000366