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Volume 66, Issue 8

activity of bedaquiline against rapidly growing nontuberculous mycobacteria Open Access

Abstract

Bedaquiline (BDQ) has been proven to be effective in the treatment of multidrug-resistant tuberculosis. We hypothesized that BDQ could be a potential agent to treat nontuberculous mycobacterial (NTM) infection. The objective of this study was to evaluate the activity of BDQ against rapidly growing mycobacteria by assessing the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against 18 NTM strains. For MIC determination we performed the resazurin microtitre assay broth dilution, and for the MBC the c.f.u. was determined. BDQ exhibited a strong inhibitory effect against most NTM tested; however, for some NTM strains the MBC was significantly higher than the MIC. A new finding is that has a mutation in the gene associated with natural resistance to BDQ. These preliminary promising results demonstrate that BDQ could be potentially useful for the treatment of NTM.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): atpE mutation , minimum bactericidal concentration , minimum inhibitory concentration , Mycobacterium flavescens , nontuberculous mycobacteria and resistance to bedaquiline
© 2017 The Authors
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/content/journal/jmm/10.1099/jmm.0.000537
2017-08-01
2024-04-19
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In vitro activity of bedaquiline against rapidly growing nontuberculous mycobacteria
J. Med. Microbiol. 66, 1140 (2017); https://doi.org/10.1099/jmm.0.000537
/content/journal/jmm/10.1099/jmm.0.000537
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