Extra-corporeal membrane oxygenation-associated infections: implication of extra-intestinal pathogenic Escherichia coli clones
Messika, Jonathan and Clermont, Olivier and Landraud, Luce and Schmidt, Matthieu and Aubry, Alexandra and Sougakoff, Wladimir and Fernandes, Romain and Combes, Alain and Denamur, Erick and Ricard, Jean-Damien,, 66, 1189-1195 (2017),
doi = https://doi.org/10.1099/jmm.0.000554,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Extra-corporeal membrane oxygenation (ECMO) is a promising life-saving technique for critically ill patients. Bacterial infection is a frequent complication, and Escherichia coli the predominant causative pathogen, but little is known about the characteristics of E. coli strains in these infections. We therefore conducted a retrospective study of 33 E. coli strains responsible for 33 ECMO-related infections, in 30 subjects. Antimicrobial susceptibility, phylotyping, O-typing, clonal relatedness determination and the screening for four virulence factor genes were conducted. Polymicrobial infections were evidenced in 61.6 % of episodes, irrespective of E. coli characteristics. Extra-intestinal pathogenic strains represented the large majority (69.7 %) of all E. coli isolates. Their advantageous genetic background may explain their predominance in this context. The potential for targeted digestive decontamination should be investigated in these patients for whom infectious complications are a heavy burden.,
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