1887

Abstract

To evaluate the role of infection, 96 otherwise healthy 7- to 17-year-old subjects who were suffering from a cough lasting from 2 to 8 weeks were prospectively recruited. At enrolment, a nasopharyngeal swab and an oral fluid sample were obtained to search for pertussis infection by the detection of DNA and/or an elevated titre of anti-pertussis toxin IgG. Evidence of pertussis infection was found in 18 (18.7 %; 95 % confidence interval, 11.5–28.0) cases. In 15 cases, the disease occurred despite booster administration. In two cases, pertussis was diagnosed less than 2 years after the booster injection, whereas in the other cases it was diagnosed between 2 and 9 years after the booster dose. This study used non-invasive testing to show that pertussis is one of the most important causes of long-lasting cough in school-age subjects. Moreover, the protection offered by acellular pertussis vaccines currently wanes more rapidly than previously thought.

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2017-11-01
2024-03-29
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References

  1. Shields MD, Doherty GM. Chronic cough in children. Paediatr Respir Rev 2013; 14:100–106 [View Article][PubMed]
    [Google Scholar]
  2. Hallander HO, Gnarpe J, Gnarpe H, Olin P. Bordetella pertussis, Bordetella parapertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae and persistent cough in children. Scand J Infect Dis 1999; 31:281–286[PubMed] [Crossref]
    [Google Scholar]
  3. Campbell H, Amirthalingam G, Fry NK, Litt D, Harrison TG et al. Oral fluid testing for pertussis, England and Wales, June 2007august 2009. Emerg Infect Dis 2014; 20:968–975 [View Article][PubMed]
    [Google Scholar]
  4. van den Brink G, Wishaupt JO, Douma JC, Hartwig NG, Versteegh FG. Bordetella pertussis: an underreported pathogen in pediatric respiratory infections, a prospective cohort study. BMC Infect Dis 2014; 14:526 [View Article][PubMed]
    [Google Scholar]
  5. Wendelboe AM, Van Rie A, Salmaso S, Englund JA. Duration of immunity against pertussis after natural infection or vaccination. Pediatr Infect Dis J 2005; 24:S58–S61 [View Article][PubMed]
    [Google Scholar]
  6. European Centre for Disease prevention and Control Vaccine Schedule. Pertussis Available at http://vaccine-schedule.ecdc.europa.eu/pages/scheduler.aspx [Accessed on 16 March 2017]
  7. Wang K, Fry NK, Campbell H, Amirthalingam G, Harrison TG et al. Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort study. BMJ 2014; 348:g3668 [View Article][PubMed]
    [Google Scholar]
  8. Klein NP, Bartlett J, Fireman B, Baxter R. Waning Tdap effectiveness in adolescents. Pediatrics 2016; 137:e20153326 [View Article][PubMed]
    [Google Scholar]
  9. Shields MD, Bush A, Everard ML, McKenzie S, Primhak R. Recommendations for the assessment and management of cough in children. Thorax 2008; 63:1–15 [View Article][PubMed]
    [Google Scholar]
  10. Cherry JD, Tan T, Wirsing von König CH, Forsyth KD, Thisyakorn U et al. Clinical definitions of pertussis: summary of a Global Pertussis Initiative Roundtable Meeting, February 2011. Clin Infect Dis 2012; 54:1756–1764 [View Article][PubMed]
    [Google Scholar]
  11. Tatti KM, Sparks KN, Boney KO, Tondella ML. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin Microbiol 2011; 49:4059–4066 [View Article][PubMed]
    [Google Scholar]
  12. Fry NK, Litt DJ, Duncan J, Vaghji L, Warrener L et al. Modelling anti-pertussis toxin IgG antibody decay following primary and preschool vaccination with an acellular pertussis vaccine in UK subjects using a modified oral fluid assay. J Med Microbiol 2013; 62:1281–1289 [View Article][PubMed]
    [Google Scholar]
  13. Ministero della Salute Piano Nazionale Prevenzione Vaccinale 2017–2019. Le vaccinazioni per fasce di età Available at www.salute.gov.it/imgs/C_17_pubblicazioni_2571_allegato.pdf [Accessed on 15 March 2017]
  14. Versteegh FG, Weverling GJ, Peeters MF, Wilbrink B, Veenstra-van Schie MT et al. Community-acquired pathogens associated with prolonged coughing in children: a prospective cohort study. Clin Microbiol Infect 2005; 11:801–807 [View Article][PubMed]
    [Google Scholar]
  15. Philipson K, Goodyear-Smith F, Grant CC, Chong A, Turner N et al. When is acute persistent cough in school-age children and adults whooping cough? A prospective case series study. Br J Gen Pract 2013; 63:e573579 [View Article][PubMed]
    [Google Scholar]
  16. Shields MD. Pertussis: a significant cause of prolonged acute cough in previously vaccinated school-aged children. Evid Based Med 2015; 20:35 [View Article][PubMed]
    [Google Scholar]
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