1887

Abstract

Virulent genotypes of have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of by type of chronic gastritis; (ii) to describe the frequency of , and genotypes in strains from patients with different types of chronic gastritis; (iii) to characterize the variable region of alleles.

A total of 164 patients with chronic gastritis were studied. Altogether, 50 strains were isolated, and the status of , and genotypes was examined by PCR. EPIYA segment identification was performed using PCR and sequencing of fragments of six randomly selected strains.

The overall prevalence of was 30.5 %. Eighty percent of the isolated strains were , and the and genes were detected in 74 and 32 % of the strains, respectively. The most frequent genotypes were and v , with 40 % (20/50) and 28 % (14/50), respectively. In , the most frequent EPIYA motif was -ABC (78.4 %), and EPIYA-ABCC and -ABCCC motifs were found in 10.8 % of the strains. A modified EPIYT-B motif was found in 66.6 % of the sequenced strains.

strains carrying , and genotypes were the most prevalent in patients with chronic gastritis from the south of Mexico. In the strains, the EPIYA-ABC motif was the most common.

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2018-03-01
2024-03-29
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