@article{mbs:/content/journal/jmm/10.1099/jmm.0.000709, author = "Trinh, Huan and Yoo, Youngchul and Won, Kyung-Hwa and Ngo, Hien T. T. and Yang, Jung-Eun and Cho, Jin-Gyeong and Lee, Sang-Won and Kim, Ki-Young and Yi, Tae-Hoo", title = "Evaluation of in-vitro antimicrobial activity of Artemisia  apiacea H. and Scutellaria baicalensis G. extracts", journal= "Journal of Medical Microbiology", year = "2018", volume = "67", number = "4", pages = "489-495", doi = "https://doi.org/10.1099/jmm.0.000709", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000709", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "Scutellaria baicalensis G.", keywords = "antifungal", keywords = "Artemisia apiacea H.", keywords = "MIC", keywords = "antibacterial", abstract = " Purpose. In traditional Korean medicine, Artemisia apiacea H. (ART) and Scutellaria baicalensis G. (SCU) are combined for the treatment of malaria and other malaria-like diseases. Because SCU is well-known as an antibacterial agent, the antimicrobial effect of a mixture of ART and SCU was investigated. Methodology. Plant samples were purchased from Kyungdong mart and extracted with 70 % ethanol. The in vitro antimicrobial activity of ART and SCU against pathogenic fungi (Aspergillus niger, Aspergillus oryzae, Candida albicans, Candida tropicalis and Candida glabrata), Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) was evaluated using a broth microdilution assay, modified-disc diffusion and agar dilution methods with further CH2Cl2-fractionated ART, SCU and a mixture of ART/SCU (at a ratio of 3 : 5) (THAN-1). Results. ART and SCU were effective against A. niger, C. albicans, B. subtilis and S. aureus. The range of minimum inhibitory concentration (MIC) values was 0.03125 to 4 mg ml−1 in the ART and SCU treatments. ART exhibited stronger activity than SCU. Interestingly, a 3 : 5 ratio mixture of ART and SCU (THAN-1) showed stronger antimicrobial activity than ART or SCU used individually. Conclusion. A treatment using a mixture of herbs such as THAN-1 would be useful in the suppression of the growth of pathogenic bacterial and fungal strains.", }