Characterization of SCCmec type IV methicillin-resistant Staphylococcus aureus clones increased in Japanese hospitals Nakaminami, Hidemasa and Takadama, Shunsuke and Ito, Ayumu and Hasegawa, Mariko and Jono, Chika and Noguchi, Miyuki and Shoshi, Manami and Wajima, Takeaki and Fujii, Takeshi and Maruyama, Hiroshi and Sakamoto, Haruo and Ito, Yutaka and Okamoto, Satsuki and Masaki, Yukiyoshi and Tsuchiya, Kayoko and Nishinarita, Susumu and Noguchi, Norihisa,, 67, 769-774 (2018), doi = https://doi.org/10.1099/jmm.0.000735, publicationName = Microbiology Society, issn = 0022-2615, abstract= Recently, the prevalence of staphylococcal cassette chromosome mec (SCCmec) type IV isolates, which are the major community-acquired methicillin-resistant Staphylococcus aureus (MRSA), have increased in Japanese hospitals. The aim of this study was to elucidate the detailed molecular epidemiological features of the SCCmec type IV clones in Japanese hospitals. When 2589 MRSA isolated from four hospitals in Tokyo, Japan between 2010 and 2014 were analysed, the proportion of SCCmec type IV overtook that of type II, which was the major type of hospital-acquired MRSA in 2014. Multilocus sequence typing showed that CC1 was the most predominant clone in the SCCmec type IV isolates. The clinical departments that the patients belonged to, pulsed-field gel electrophoresis analysis and antimicrobial susceptibility profiles suggested that the origin of the CC1-SCCmec type IV (CC1-IV) clone was a community setting. Our data show that the CC1-IV clone is becoming a predominant MRSA clone in Japanese hospitals., language=, type=