Validation of a plasma metabolomics model that allows anticipation of the occurrence of cytomegalovirus DNAaemia in allogeneic stem cell transplant recipients Monleón, Daniel and Talaya, Alberto and Giménez, Estela and Vinuesa, Víctor and Morales, José Manuel and Hernández-Boluda, Juan Carlos and Pérez, Ariadna and Piñana, José Luis and Solano, Carlos and Navarro, David,, 67, 814-819 (2018), doi = https://doi.org/10.1099/jmm.0.000746, publicationName = Microbiology Society, issn = 0022-2615, abstract= A plasma metabolomic model obtained by means of untargeted 1H nuclear magnetic resonance, to which taurine, choline, methylamine, total glutathione, trimethylamine N-oxide, lactate, lysine, isoleucine, total fatty acids and unsaturated fatty acids contributed, was validated for the prediction of first episodes of cytomegalovirus (CMV) DNAaemia in a cohort of 79 allogeneic stem haematopoietic stem cell transplant (allo-HSCT) recipients. The predictive success rate was nearly 65 % for patients at both low and high risk of CMV-related complications according to their baseline characteristics. Plasma metabolomics profiling shortly after engraftment (day 21 after transplantation) allowed the anticipation of the occurrence of CMV DNAaemia in 71 % of patients. Plasma metabolomics analyses may be ancillary for identifying allo-HSCT patients at the highest risk of CMV DNAaemia who may benefit from early targeted antiviral prophylaxis., language=, type=