@article{mbs:/content/journal/jmm/10.1099/jmm.0.000842, author = "Uechi, Kohei and Tada, Tatsuya and Sawachi, Yusuke and Hishinuma, Tomomi and Takaesu, Rei and Nakama, Mika and Nakasone, Isamu and Kirikae, Teruo and Fujita, Jiro", title = "A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 β-lactamase", journal= "Journal of Medical Microbiology", year = "2018", volume = "67", number = "11", pages = "1535-1537", doi = "https://doi.org/10.1099/jmm.0.000842", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000842", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "Aeromonas hydrophila", keywords = "carbapenem-resistant", keywords = "carbapenemase", keywords = "GES-24", abstract = "Several species of Aeromonas produce the enzyme CphA metallo-β-lactamase. This study describes an isolate of Aeromonas hydrophila harbouring an acquired gene encoding the carbapenemase GES-24. This isolate was obtained from an inpatient in Okinawa, Japan, with no apparent record of travelling overseas. The minimum inhibitory concentrations of carbapenems against this isolate were 8 µg ml−1 for imipenem and 16 µg ml−1 for meropenem. Recombinant GES-24 hydrolyzed all of the tested β-lactams, including imipenem and meropenem. The genomic environment surrounding bla GES-24 was intI1-bla GES-24 -aac(6′)-IIc-qacEdelta1-sulI-orfX-tetR-tetE. This is the first report of A. hydrophila producing a GES-type carbapenemase.", }