A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 β-lactamase
Uechi, Kohei and Tada, Tatsuya and Sawachi, Yusuke and Hishinuma, Tomomi and Takaesu, Rei and Nakama, Mika and Nakasone, Isamu and Kirikae, Teruo and Fujita, Jiro,, 67, 1535-1537 (2018),
doi = https://doi.org/10.1099/jmm.0.000842,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= Several species of Aeromonas produce the enzyme CphA metallo-β-lactamase. This study describes an isolate of Aeromonas hydrophila harbouring an acquired gene encoding the carbapenemase GES-24. This isolate was obtained from an inpatient in Okinawa, Japan, with no apparent record of travelling overseas. The minimum inhibitory concentrations of carbapenems against this isolate were 8 µg ml−1 for imipenem and 16 µg ml−1 for meropenem. Recombinant GES-24 hydrolyzed all of the tested β-lactams, including imipenem and meropenem. The genomic environment surrounding bla GES-24 was intI1-bla GES-24 -aac(6′)-IIc-qacEdelta1-sulI-orfX-tetR-tetE. This is the first report of A. hydrophila producing a GES-type carbapenemase.,
language=,
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