RT Journal Article SR Electronic(1) A1 Aghamali, Mina A1 Sedighi, Mansour A1 Zahedi bialvaei, Abed A1 Mohammadzadeh, Nima A1 Abbasian, Sara A1 Ghafouri, Zahra A1 Kouhsari, EbrahimYR 2019 T1 Fosfomycin: mechanisms and the increasing prevalence of resistance JF Journal of Medical Microbiology, VO 68 IS 1 SP 11 OP 25 DO https://doi.org/10.1099/jmm.0.000874 PB Microbiology Society, SN 1473-5644, AB There are challenges regarding increased global rates of microbial resistance and the emergence of new mechanisms that result in microorganisms becoming resistant to antimicrobial drugs. Fosfomycin is a broad-spectrum bactericidal antibiotic effective against Gram-negative and certain Gram-positive bacteria, such as Staphylococci, that interfere with cell wall synthesis. During the last 40 years, fosfomycin has been evaluated in a wide range of applications and fields. Although numerous studies have been done in this area, there remains limited information regarding the prevalence of resistance. Therefore, in this review, we focus on the available data concerning the mechanisms and increasing resistance regarding fosfomycin., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000874