1887

Abstract

The study was arranged to assess the actual rates of colonization of pregnant women and their children with group B streptococcus (GBS) in a Polish university hospital. Resistance of these cocci to macrolides and clindamycin was also tested and routes of transmission of GBS were followed in some cases using molecular typing. Colonization with GBS was checked in 340 pregnant women living in the south-eastern region of Poland (Małopolska) in the years 2004–2006. Women with a complicated pregnancy were more often colonized than those with a normal pregnancy (20.0 % versus 17.2 %). Moreover, women with a complicated pregnancy were twice as often colonized with GBS strains with the MLS phenotype indicating resistance to macrolides and clindamycin. Regarding neonatal colonization by GBS, we found that neonates born from the colonized mothers with a complicated pregnancy were more often colonized with GBS than those from the mothers with a normal pregnancy (35 % versus 26.7 %). By molecular typing of the GBS strains isolated from mothers and their newborns we have been able to suggest the possibility of horizontal transmission of the strains from the hospital environment to newborns. Our results clearly indicate that rates of GBS colonization among pregnant women and neonates in a Polish university hospital have reached levels comparable to those reported in other European clinical centres.

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2009-02-01
2024-03-29
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References

  1. Artz L. A., Kempf V. A., Autenrieth I. B. 2003; Rapid screening for Streptococcus agalactiae in vaginal specimens of pregnant women by fluorescent in situ hybridization. J Clin Microbiol 41:2170–2173 [CrossRef]
    [Google Scholar]
  2. Benitz W. E., Gould J. B., Druzin M. L. 1999; Risk factors for early-onset group B streptococcal sepsis: estimation of odds ratios by critical literature review. Pediatrics 103:e77 [CrossRef]
    [Google Scholar]
  3. Brimil N., Barthell E., Heindrichs U., Kuhn M., Lutticken R., Spellerberg B. 2006; Epidemiology of Streptococcus agalactiae colonization in Germany. Int J Med Microbiol 296:39–44
    [Google Scholar]
  4. CDC 1996; Prevention of perinatal group B streptococcal disease: a public health perspective. MMWR 45:1–24
    [Google Scholar]
  5. Chohan L., Hollier L. M., Bishop K., Kilpatrick C. C. 2006; Patterns of antibiotic resistance among group B streptococcus isolates: 2001–2004. Infect Dis Obstet Gynecol 200657492
    [Google Scholar]
  6. Christie R., Atkins N. E., Munch-Peterson E. 1944; A note on a lytic phenomenon shown by group B streptococci. Aust J Exp Biol 22:197–200 [CrossRef]
    [Google Scholar]
  7. de la Rosa Fraile M., Cabero L., Andreu A., Rao G. G. 2001; Prevention of group B streptococcal neonatal disease: a plea for a European consensus. Clin Microbiol Infect 7:25–27
    [Google Scholar]
  8. Desjardins M., Delgaty K. L., Ramotar K., Seetaram C., Toye B. 2004; Prevalence and mechanisms of erythromycin resistance in group A and group B streptococcus: implications for reporting susceptibility results. J Clin Microbiol 42:5620–5623 [CrossRef]
    [Google Scholar]
  9. Fanaro S., Chierici R., Guerrini P., Vigi V. 2003; Intestinal microflora in early infancy: composition and development. Acta Paediatr Suppl 91:48–55
    [Google Scholar]
  10. Galińska A., Szponar M., Bohdan Z. 2001; B Streptococcus and other pathogenic bacteria colonization in hospitals in the Gdansk Metro Area. Przegl Epidemiol 55:Suppl.55–61
    [Google Scholar]
  11. Hajdu A., Blystad H., Høiby E. A., Klouman E., Schimmer B., Nygård K. 2006; Unexpected increase in case fatality of invasive group B streptococcal infections in infants in Norway, January-July 2006. Euro Surveill 11:E060727–2
    [Google Scholar]
  12. Ke D., Menard C., Picard F. J., Boissinot M., Ouellette M., Roy P. H., Bergeron M. G. 2000; Development of conventional and real-time PCR assays for the rapid detection of group B streptococci. Clin Chem 46:324–331
    [Google Scholar]
  13. Kowalska B., Niemiec K. T., Drejewicz H., Polak K., Kubik P., Elmidaoui A., Gierowska-Bogusz B., Jaczynska R. 2003; Prevalence of group B streptococcal colonization in pregnant women and their newborns based on the results of examination of patients in the Obstetric and Gynecology Department of the National Research Institute of Mother and Child – a pilot study. Ginekol Pol 74:1223–1227
    [Google Scholar]
  14. Martinez G., Harel J., Higgins R., Lacouture S., Daignault D., Gottschalk M. 2000; Characterization of Streptococcus agalactiae isolates of bovine and human origin by randomly amplified polymorphic DNA analysis. J Clin Microbiol 38:71–78
    [Google Scholar]
  15. Puopolo K. M., Madoff L. C., Eichenwald E. C. 2005; Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics 115:1240–1246 [CrossRef]
    [Google Scholar]
  16. Rotimi V. O., Olowe S. A., Ahmed I. 1985; The development of bacterial flora of premature neonates. J Hyg (Lond 94:309–318 [CrossRef]
    [Google Scholar]
  17. Schrag S., Gorwitz R., Fultz-Butts K., Schuchat A. 2002; Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR Recomm Rep 51:1–22
    [Google Scholar]
  18. Schuchat A. 2000; Neonatal group B streptococcal disease: screening and prevention. N Engl J Med 343:209–210 [CrossRef]
    [Google Scholar]
  19. Trijbels-Smeulders M. A., Kollee L. A., Adriaansee A. H., Kimpen J. L., Gerards L. J. 2004; Neonatal group B streptococcal infection: incidence and strategies for prevention in Europe. Pediatr Infect Dis J 23:172–173 [CrossRef]
    [Google Scholar]
  20. Tsolia M., Psoma M., Gavrili S., Petrochilou V., Michalas S., Legakis N., Karpathios T. 2003; Group B streptococcus colonization of Greek pregnant women and neonates: prevalence, risk factors and serotypes. Clin Microbiol Infect 9:832–838 [CrossRef]
    [Google Scholar]
  21. Welch D. F., Aldridge K. E. 2005; Optimizing the rapid and accurate detection of group B streptococci from antepartum cultures. Infect Med 22:133–137
    [Google Scholar]
  22. Wiercinska-Drapalo A., Jaroszewicz J., Flisiak R., Prokopowicz D. 2005; Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland. World J Gastroenterol 11:2630–2633 [CrossRef]
    [Google Scholar]
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