RT Journal Article SR Electronic(1) A1 O'Neill, Eoghan A1 Humphreys, Hilary A1 O'Gara, James P.YR 2009 T1 Carriage of both the fnbA and fnbB genes and growth at 37 °C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates JF Journal of Medical Microbiology, VO 58 IS 4 SP 399 OP 402 DO https://doi.org/10.1099/jmm.0.005504-0 PB Microbiology Society, SN 1473-5644, AB The Staphylococcus aureus FnBPA and FnBPB proteins promote acid-induced biofilm accumulation. Meticillin-resistant S. aureus (MRSA) isolates from device-related infections with both fnbA and fnbB produced significantly more biofilm than isolates with either gene alone. Under mildly acidic growth conditions, FnBP-mediated biofilm and fnbA and fnbB transcript levels were substantially higher during growth at 37 °C than at 30 °C. Thus, in addition to a lowered pH, carriage of both fnbA and fnbB and growth at 37 °C promote MRSA biofilm development, further supporting a role for the FnBPA and FnBPB surface proteins in the pathogenesis of MRSA device-related infections., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.005504-0