Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum
Matějková, Petra and Flasarová, Magdalena and Zákoucká, Hana and Bořek, Milan and Křemenová, Soňa and Arenberger, Petr and Woznicová, Vladana and Weinstock, George M. and Šmajs, David,, 58, 832-836 (2009),
doi = https://doi.org/10.1099/jmm.0.007542-0,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.,
language=,
type=