1887

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Volume 59, Issue 3

Vaginal colonization and activity of the probiotic bacterium L23 in a murine model of vaginal tract infection Free

Abstract

A strain of , identified as L23, was selected from among 100 strains isolated from vaginal swabs of healthy, non-pregnant, pre-menopausal women. L23 was chosen on the basis of its bacteriocinogenic ability and its properties relevant to colonization, i.e. self-aggregation, adherence to vaginal epithelial cells and co-aggregation with bacterial pathogens. The antimicrobial preventative and curative effects produced by the probiotic L23 administered locally against in a murine vaginal tract infection model were studied. One dose of the human strain L23 containing 10 c.f.u. ml colonized and persisted in the vaginal tract of the female BALB/c mice for 5 days. Infection with the pathogen at 10 c.f.u. ml in the vaginal tract was maintained for more than 7 days. A single dose of L23 administered 24 h pre-infection inhibited growth on day 3 post-infection, showing the preventative effect displayed by this strain Treatment with L23 during the post-infection period showed complete inhibition of pathogen growth from day 5. Thus, this study indicated that the probiotic bacterium L23 produced both preventative and curative effects on growth. The beneficial properties and the production of antimicrobial metabolites may act to inhibit a pathogenic micro-organism within the vaginal environment. Strain L23 could be a good natural alternative to other therapies used for genital infections.

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  • Accepted:
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/content/journal/jmm/10.1099/jmm.0.012583-0
2010-03-01
2024-04-16
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Vaginal colonization and activity of the probiotic bacterium Lactobacillus fermentum L23 in a murine model of vaginal tract infection
J. Med. Microbiol. 59, 360 (2010); https://doi.org/10.1099/jmm.0.012583-0
/content/journal/jmm/10.1099/jmm.0.012583-0
/content/journal/jmm/10.1099/jmm.0.012583-0
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