@article{mbs:/content/journal/jmm/10.1099/jmm.0.018119-0, author = "Ko, Kwan Soo and Lee, Ji-Young and Baek, Jin Yang and Suh, Ji-Yoeun and Lee, Mi Young and Choi, Ji Young and Yeom, Joon-Sup and Kim, Yeon-Sook and Jung, Sook-In and Shin, Sang Yop and Heo, Sang Taek and Kwon, Ki Tae and Son, Jun Seong and Kim, Shin-Woo and Chang, Hyun-Ha and Ki, Hyun Kyun and Chung, Doo Ryeon and Peck, Kyong Ran and Song, Jae-Hoon", title = "Predominance of an ST11 extended-spectrum β-lactamase-producing Klebsiella pneumoniae clone causing bacteraemia and urinary tract infections in Korea", journal= "Journal of Medical Microbiology", year = "2010", volume = "59", number = "7", pages = "822-828", doi = "https://doi.org/10.1099/jmm.0.018119-0", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.018119-0", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", keywords = "KNUH, Kyungpook National University Hospital", keywords = "ST, sequence type", keywords = "ConNUH, Chonnam National University Hospital", keywords = "JNUH, Jeju National University Hospital", keywords = "GNUH, Gyeongsang National University Hospital", keywords = "CunNUH, Chungnam National University Hospital", keywords = "KSH, Kangbuk Samsung Hospital", keywords = "UTI, urinary tract infection", keywords = "ESBL, extended-spectrum β-lactamase", keywords = "KUH, Konkuk University Hospital", keywords = "CubNUH, Chungbuk National University Hospital", keywords = "SMC, Samsung Medical Center", keywords = "MLST, multilocus sequence typing", keywords = "DFH, Daegu Fatima Hospital", abstract = "To investigate the antimicrobial resistance, extended-spectrum β-lactamases (ESBLs) and clones of Klebsiella pneumoniae isolates causing bacteraemia or urinary tract infection (UTI) in Korea, a total of 406 K. pneumoniae isolates from patients with bacteraemia (221 isolates) and UTI (185 isolates) were collected from 10 tertiary-care Korean hospitals from July 2006 to October 2007. In vitro antimicrobial susceptibility testing was performed for all isolates and ESBL production was tested. Multilocus sequence typing (MLST) analyses were performed to characterize genotypes of ESBL-producing K. pneumoniae isolates. PFGE was performed for sequence type 11 (ST11) isolates. Forty-seven UTI isolates (25.4 %) produced ESBLs, while 30 bacteraemia isolates (13.6 %) produced ESBLs (P=0.002). Among 77 ESBL-producing isolates, thirty-two (41.6 %) produced SHV-type ESBLs. bla CTX-M genes such as bla CTX-M-14 and bla CTX-M-15 were detected in 36.4 %. MLST and PFGE analyses showed that ST11 was dominant in ESBL-producing K. pneumoniae isolates causing UTI (57.4 %) and in those causing bacteraemia (70.0 %) and has been prevalent in Korean hospitals. ST11 isolates harbour a combination of different ESBL genes. The ST11 clone of ESBL-producing K. pneumoniae isolates prevails in Korea, but most isolates might acquire ESBL genes independently or several different clones might be distributed in Korea.", }