1887

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Volume 59, Issue 12

Determination of urinary -/-arabinitol ratios as a biomarker for invasive candidiasis in children with cardiac diseases Free

Abstract

A non-invasive, non-culture-based method of determining urinary -/-arabinitol (-/-ARA) ratios was investigated as a tool for the diagnosis of invasive candidiasis in nosocomial paediatric infection cases. The study encompassed 138 children aged 4 days to 16 years (mean±=1.6±4.2 years) with congenital heart defects (91.4 %) or with rhythm disorders or circulatory failure (8.6 %). ARA enantiomers were detected by GC using an electron capture detector. Positive -/-ARA ratios were found for 11/11 patients with proven candidiasis and 17/19 patients with clinically suspected invasive candidiasis. Thirty children were undergoing antifungal chemotherapy. -/-ARA ratios (mean±) were 2.601±0.544 in hospitalized cardiac patients without fungal infection and 5.120±1.253 in those receiving antifungal therapy (<0.001). The sensitivity of the method was 100 %, the specificity 97.2 %, the positive predictive value was 78.6 % and the negative predictive value was 100 %.

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Keyword(s): ARA, arabinitol , NPV, negative predictive value and PPV, positive predictive value
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2010-12-01
2024-04-26
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Determination of urinary d-/l-arabinitol ratios as a biomarker for invasive candidiasis in children with cardiac diseases
J. Med. Microbiol. 59, 1490 (2010); https://doi.org/10.1099/jmm.0.018135-0
/content/journal/jmm/10.1099/jmm.0.018135-0
/content/journal/jmm/10.1099/jmm.0.018135-0
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