1887

Abstract

Human tuberculosis caused by is rare, but its prevalence and clinical significance may have been underestimated. To the best of our knowledge, 21 cases have been reported in the literature in the last decade. We report six recent pulmonary cases caused by over a period of 5 years detected in French clinical mycobacteriology laboratories of the hospital network. Our data confirm the potential of to cause clinical illness in immunocompetent patients. grew slowly from specimens, delaying the final microbiological diagnosis. Therefore, patients with tuberculosis caused by could benefit from the use of rapid diagnostic molecular techniques directly on clinical samples. From a review of the literature and this study, a classical antituberculous therapy seems effective in treating patients with disease.

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2010-08-01
2024-03-28
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References

  1. Brodin P., Eiglmeier K., Marmiesse M., Billault A., Garnier T., Niemann S., Cole S. T., Brosch R. 2002; Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect Immun 70:5568–5578 [CrossRef]
    [Google Scholar]
  2. Brudey K., Driscoll J. R., Rigouts L., Prodinger W. M., Gori A., Al-Hajoj S. A., Allix C., Aristimuño L., Arora J. other authors 2006; Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology. BMC Microbiol 6:23 [CrossRef]
    [Google Scholar]
  3. de Jong E., Rentenaar R. J., van Pelt R., de Lange W., Schreurs W., van Soolingen D., Sturm P. D. J. 2009; Two cases of Mycobacterium microti -induced culture-negative tuberculosis. J Clin Microbiol 47:3038–3040 [CrossRef]
    [Google Scholar]
  4. Emmanuel F. X., Seagar A.-L., Doig C., Rayner A., Claxton P., Laurenson I. 2007; Human and animal infections with Mycobacterium microti , Scotland. Emerg Infect Dis 13:1924–1927 [CrossRef]
    [Google Scholar]
  5. Foudraine N. A., van Soolingen D., Noordhoek G. T., Reiss P. 1998; Pulmonary tuberculosis due to Mycobacterium microti in a human immunodeficiency virus-infected patient. Clin Infect Dis 27:1543–1544 [CrossRef]
    [Google Scholar]
  6. Frank W., Reisinger E. C., Brandt-Hamerla W., Schwede I., Handrick W. 2009; Mycobacterium microti – pulmonary tuberculosis in an immunocompetent patient. Wien Klin Wochenschr 121:282–286 [CrossRef]
    [Google Scholar]
  7. Geiss H. K., Feldhues R., Niemann S., Nolte O., Rieker R. 2005; Landouzy septicemia (sepsis tuberculosa acutissima) due to Mycobacterium microti in an immunocompetent man. Infection 33:393–396 [CrossRef]
    [Google Scholar]
  8. Horstkotte M. A., Sobottka I., Schewe C. K., Schäfer P., Laufs R., Rüsch-Gerdes S., Niemann S. 2001; Mycobacterium microti llama-type infection presenting as pulmonary tuberculosis in a human immunodeficiency virus-positive patient. J Clin Microbiol 39:406–407 [CrossRef]
    [Google Scholar]
  9. Jenkins N. E., Beadsworth M. B., Anson J. J., Nye F. J., Martlew V. J., Beeching N. J. 2006; Immune restoration disease in HIV patient. Emerg Infect Dis 12:689–691 [CrossRef]
    [Google Scholar]
  10. Kremer K., van Soolingen D., van Embden J., Hughes S., Inwald J., Hewinson G. 1998; Mycobacterium microti : more widespread than previously thought. J Clin Microbiol 36:2793–2794
    [Google Scholar]
  11. Niemann S., Richter E., Dalugge-Tamm H., Schlesinger H., Graupner D., Konigstein B., Gurath G., Greinert U., Rusch-Gerdes S. 2000; Two cases of Mycobacterium microti derived tuberculosis in HIV-negative immunocompetent patients. Emerg Infect Dis 6:539–542 [CrossRef]
    [Google Scholar]
  12. Restrepo B. I., Fisher-Hoch S. P., Pino P. A., Salinas A., Rahbar M. H., Mora F., Cortes-Penfield N., McCormick J. B. 2008; Tuberculosis in poorly controlled type 2 diabetes: altered cytokine expression in peripheral white blood cells. Clin Infect Dis 47:634–641 [CrossRef]
    [Google Scholar]
  13. van Soolingen D., van der Zanden A. G., de Haas P. E., Noordhoek G. T., Kiers A., Foudraine N. A., Portaels F., Kolk A. H., Kremer K., van Embden J. D. 1998; Diagnosis of Mycobacterium microti infections among humans by using novel genetic markers. J Clin Microbiol 36:1840–1845
    [Google Scholar]
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