1887

Abstract

Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1–30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated duodenal ulcer promoter gene A () using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test <0.05). -positive was detected not only in DU patients (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity in patients with -positive than in those with -negative (<0.05). The occurrence of GCa was significantly lower in patients with -positive and a high BAO level (log-rank test <0.05). DUs, higher acid output and -positive were negatively associated with GCa.

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2010-12-01
2024-03-29
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References

  1. Arachchi H. S., Kalra V., Lal B., Bhatia V., Baba C. S., Chakravarthy S., Rohatgi S., Sarma P. M., Mishra V. other authors 2007; Prevalence of duodenal ulcer-promoting gene ( dupA ) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter 12:591–597 [CrossRef]
    [Google Scholar]
  2. Argent R. H., Burette A., Miendje Deyi V. Y., Atherton J. C. 2007; The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America. Clin Infect Dis 45:1204–1206 [CrossRef]
    [Google Scholar]
  3. Correa P. 1988; A human model of gastric carcinogenesis. Cancer Res 48:3554–3560
    [Google Scholar]
  4. Douraghi M., Mohammadi M., Oghalaie A., Abdirad A., Mohagheghi M. A., Hosseini M. E., Zeraati H., Ghasemi A., Esmaieli M., Mohajerani N. 2008; dupA as a risk determinant in Helicobacter pylori infection. J Med Microbiol 57:554–562 [CrossRef]
    [Google Scholar]
  5. Gomes L. I., Rocha G. A., Rocha A. M., Soares T. F., Oliveira C. A., Bittencourt P. F., Queiroz D. M. 2008; Lack of association between Helicobacter pylori infection with dupA -positive strains and gastroduodenal diseases in Brazilian patients. Int J Med Microbiol 298:223–230 [CrossRef]
    [Google Scholar]
  6. Haruma K., Suzuki T., Tsuda T., Yoshihara M., Sumii K., Kajiyama G. 1991; Evaluation of tumor growth rate in patients with early gastric carcinoma of the elevated type. Gastrointest Radiol 16:289–292 [CrossRef]
    [Google Scholar]
  7. Haruma K., Kawaguchi H., Kohmoto K., Okamoto S., Yoshihara M., Sumii K., Kajiyama G. 1995; Helicobacter pylori infection, serum gastrin, and gastric acid secretion in teen-age subjects with duodenal ulcer, gastritis, or normal mucosa. Scand J Gastroenterol 30:322–326
    [Google Scholar]
  8. Hatakeyama M. 2009; Helicobacter pylori and gastric carcinogenesis. J Gastroenterol 44:239–248 [CrossRef]
    [Google Scholar]
  9. Hiyama T., Tanaka S., Masuda H., Shima H., Kose K., Tuncel H., Ito M., Kitadai Y., Sumii M. other authors 2003; Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan. J Gastroenterol Hepatol 18:1202–1207 [CrossRef]
    [Google Scholar]
  10. Hussein N. R. 2010; The association of dupA and Helicobacter pylori -related gastroduodenal diseases. Eur J Clin Microbiol Infect Dis 29:817–821 [CrossRef]
    [Google Scholar]
  11. Hussein N. R., Mohammadi M., Talebkhan Y., Doraghi M., Letley D. P., Muhammad M. K., Argent R. H., Atherton J. C. 2008; Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori -associated disease. J Clin Microbiol 46:1774–1779 [CrossRef]
    [Google Scholar]
  12. Hussein N. R., Argent R. H., Marx C. K., Patel S. R., Robinson K., Atherton J. C. 2010; Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells. J Infect Dis 202:261–269 [CrossRef]
    [Google Scholar]
  13. IARC 2002 Cancer Incidence in Five Continents vol. VIII Edited by Parkin D. M., Whelan S. L., Ferlay J., Teppo L., Thomas D. B. Lyon: International Agency; for Research on Cancer (World Health Organization) http://www.iarc.fr/en/publications/pdfs-online/epi/sp155/index.php
    [Google Scholar]
  14. Imagawa S., Yoshihara M., Ito M., Yoshida S., Wada Y., Tatsugami M., Takamura A., Tanaka S., Haruma K., Chayama K. 2008; Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study. Dig Dis Sci 53:1818–1823 [CrossRef]
    [Google Scholar]
  15. Ito M., Takata S., Tatsugami M., Wada Y., Imagawa S., Matsumoto Y., Takamura A., Kitamura S., Matsuo T. other authors 2009; Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy: a systematic review. J Gastroenterol 44:365–371 [CrossRef]
    [Google Scholar]
  16. Kamada T., Haruma K., Kawaguchi H., Yoshihara M., Sumii K., Kajiyama G. 1998; The association between antral G and D cells and mucosal inflammation, atrophy, and Helicobacter pylori infection in subjects with normal mucosa, chronic gastritis, and duodenal ulcer. Am J Gastroenterol 93:748–752 [CrossRef]
    [Google Scholar]
  17. Kamada T., Haruma K., Komoto K., Mihara M., Sumii K., Kajiyama G. 1999; Comparison of meal-stimulated serum gastrin response in Helicobacter pylori -positive duodenal ulcer and asymptomatic volunteers with and without H. pylori infection. Helicobacter 4:170–177 [CrossRef]
    [Google Scholar]
  18. Kodama K., Sumii K., Kawano M., Kido T., Nojima K., Sumii M., Haruma K., Yoshihara M., Chayama K. 2003; Gastric juice nitrite and vitamin C in patients with gastric cancer and atrophic gastritis: is low acidity solely responsible for cancer risk?. Eur J Gastroenterol Hepatol 15:987–993 [CrossRef]
    [Google Scholar]
  19. Lu H., Hsu P. I., Grahamm D. Y., Yamaoka Y. 2005; Duodenal ulcer promoting gene of Helicobacter pylori . Gastroenterology 128:833–848 [CrossRef]
    [Google Scholar]
  20. Ohnishi N., Yuasa H., Tanaka S., Sawa H., Miura M., Matsui A., Higashi H., Musashi M., Iwabuchi K. other authors 2008; Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci U S A 105:1003–1008 [CrossRef]
    [Google Scholar]
  21. Schmidt H. M., Andres S., Kaakoush N. O., Engstrand L., Eriksson L., Goh K. L., Fock K. M., Hilmi I., Dhamodaran S., other authors D. 2009; The prevalence of the duodenal ulcer promoting gene ( dupA ) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study. Gut Pathog 1:5 [CrossRef]
    [Google Scholar]
  22. Suzuki H., Hibi T., Marshall B. J. 2007; Helicobacter pylori : present status and future prospects in Japan. J Gastroenterol 42:1–15
    [Google Scholar]
  23. Takata S., Ito M., Wada Y., Yoshihara M., Tanaka S., Chayama K. 2009; Pathogenetic role of the tyrosine-phosphorylated CagA EPIYA sequence of Helicobacter pylori in histological gastritis in Japanese patients. J Gastroenterol 44:405–411 [CrossRef]
    [Google Scholar]
  24. Tari A., Kitadai Y., Sumii M., Sasaki A., Tani H., Tanaka S., Chayama K. 2007; Basis of decreased risk of gastric cancer in severe atrophic gastritis with eradication of Helicobacter pylori . Dig Dis Sci 52:232–239 [CrossRef]
    [Google Scholar]
  25. Ueda H., Ito M., Eguchi H., Tanaka S., Yoshihara M., Haruma K., Hatakeyama M., Chayama K. 2006; Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese. Digestion 73:47–53
    [Google Scholar]
  26. Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., Taniyama K., Sasaki N., Schlemper R. J. 2001; Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345:784–789 [CrossRef]
    [Google Scholar]
  27. Yamaoka Y. 2008; Roles of the plasticity regions of Helicobacter pylori in gastroduodenal pathogenesis. J Med Microbiol 57:545–553 [CrossRef]
    [Google Scholar]
  28. Zhang Z., Zheng Q., Chen X., Xiao S., Liu W., Lu H. 2008; The Helicobacter pylori duodenal ulcer promoting gene, dupA in China. BMC Gastroenterol 8:49 [CrossRef]
    [Google Scholar]
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