RT Journal Article SR Electronic(1) A1 Mirza, Zahid Mehmood A1 Kumar, Ashwani A1 Kalia, Nitin Pal A1 Zargar, Afzal A1 Khan, Inshad AliYR 2011 T1 Piperine as an inhibitor of the MdeA efflux pump of Staphylococcus aureus JF Journal of Medical Microbiology, VO 60 IS 10 SP 1472 OP 1478 DO https://doi.org/10.1099/jmm.0.033167-0 PB Microbiology Society, SN 1473-5644, AB Piperine, a trans-trans-isomer of 1-piperoyl-piperidine, was tested in combination with mupirocin for antimicrobial activity against Staphylococcus aureus strains including meticillin-resistant S. aureus. The combination markedly reduced the MIC of mupirocin and also lowered the mutation frequency. Enhanced accumulation and efflux of ethidium bromide from wild-type and mutant (Mupr-1) strains in the presence of piperine indicated that inhibition of efflux could be a possible mechanism of potentiation of mupirocin activity by piperine. The combination of piperine with mupirocin in a dermal infection model of mice showed better in vivo efficacy when compared with the commercially available formulation of 2 % mupirocin., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.033167-0