1887

Abstract

In this study, the frequency of extended-spectrum β-lactamases (ESBL) and plasmid-mediated quinolone resistance (PMQR) mechanisms were investigated in 206 clinical isolates of third-generation cephalosporin (3GC)-resistant in four hospitals in the Republic of Ireland. was the predominant ESBL gene. Of these 3GC resistant isolates, 54 % were also resistant to ciprofloxacin. Investigation of the PMQR mechanisms revealed that the gene predominated in fluoroquinolone-resistant (FQR) strains of and , while the gene predominated in the FQR strains of . The gene was frequently identified with the gene but was not always on the same plasmid. The prevalence of the gene appeared to be hospital-dependent. The epidemiology of both ESBL-producing and PMQR strains within the four hospitals indicated that their prevalence is not due to the spread of these resistance genes between isolates from different hospitals.

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2012-01-01
2024-03-29
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