1887

Abstract

We describe a clinical case of an abdominal abscess due to NDM-1-producing in a 35-year-old Spanish patient after hospitalization in India for perforated appendicitis and peritonitis. The strain belonged to the MLST type 231 and had multiple additional antibiotic resistance genes such as , methylase, , , and and lack of porin genes and . The patient was cured after abscess drainage.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.043190-0
2012-06-01
2024-04-30
Loading full text...

Full text loading...

/deliver/fulltext/jmm/61/6/864.html?itemId=/content/journal/jmm/10.1099/jmm.0.043190-0&mimeType=html&fmt=ahah

References

  1. Carattoli A., Bertini A., Villa L., Falbo V., Hopkins K. L., Threlfall E. J. 2005; Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63:219–228 [View Article][PubMed]
    [Google Scholar]
  2. Curiao T., Morosini M. I., Ruiz-Garbajosa P., Robustillo A., Baquero F., Coque T. M., Cantón R. 2010; Emergence of blakpc-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain. J Antimicrob Chemother 65:1608–1614 [View Article][PubMed]
    [Google Scholar]
  3. Fritsche T. R., Castanheira M., Miller G. H., Jones R. N., Armstrong E. S. 2008; Detection of methyltransferases conferring high-level resistance to aminoglycosides in Enterobacteriaceae from Europe, North America, and Latin America. Antimicrob Agents Chemother 52:1843–1845 [View Article][PubMed]
    [Google Scholar]
  4. Gaibani P., Ambretti S., Berlingeri A., Cordovana M., Farruggia P., Panico M., Landini M. P., Sambri V. 2011; Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. Euro Surveill 16:20027[PubMed]
    [Google Scholar]
  5. Jacoby G., Cattoir V., Hooper D., Martínez-Martínez L., Nordmann P., Pascual A., Poirel L., Wang M. 2008; qnr gene nomenclature. Antimicrob Agents Chemother 52:2297–2299 [View Article][PubMed]
    [Google Scholar]
  6. Kaczmarek F. M., Dib-Hajj F., Shang W., Gootz T. D. 2006; High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of blaACT-1 β-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin PhoE. Antimicrob Agents Chemother 50:3396–3406 [View Article][PubMed]
    [Google Scholar]
  7. Kumarasamy K. K., Toleman M. A., Walsh T. R., Bagaria J., Butt F., Balakrishnan R., Chaudhary U., Doumith M., Giske C. G. other authors 2010; Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 10:597–602 [View Article][PubMed]
    [Google Scholar]
  8. Lee J. C., Oh J. Y., Cho J. W., Park J. C., Kim J. M., Seol S. Y., Cho D. T. 2001; The prevalence of trimethoprim-resistance-conferring dihydrofolate reductase genes in urinary isolates of Escherichia coli in Korea. J Antimicrob Chemother 47:599–604 [View Article][PubMed]
    [Google Scholar]
  9. Miriagou V., Cornaglia G., Edelstein M., Galani I., Giske C. G., Gniadkowski M., Malamou-Lada E., Martinez-Martinez L., Navarro F. other authors 2010; Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues. Clin Microbiol Infect 16:112–122 [View Article][PubMed]
    [Google Scholar]
  10. Mulvey M. R., Grant J. M., Plewes K., Roscoe D., Boyd D. A. 2011; New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada. Emerg Infect Dis 17:103–106 [View Article][PubMed]
    [Google Scholar]
  11. Oteo J., Delgado-Iribarren A., Vega D., Bautista V., Rodríguez M. C., Velasco M., Saavedra J. M., Pérez-Vázquez M., García-Cobos S. other authors 2008; Emergence of imipenem resistance in clinical Escherichia coli during therapy. Int J Antimicrob Agents 32:534–537 [View Article][PubMed]
    [Google Scholar]
  12. Oteo J., Hernández-Almaraz J. L., Gil-Antón J., Vindel A., Fernández S., Bautista V., Campos J. 2010; Outbreak of Vim-1-carbapenemase-producing Enterobacter cloacae in a pediatric intensive care unit. Pediatr Infect Dis J 29:1144–1146 [View Article][PubMed]
    [Google Scholar]
  13. Pitart C., Solé M., Roca I., Fàbrega A., Vila J., Marco F. 2011; First outbreak of a plasmid-mediated carbapenem-hydrolyzing OXA-48 β-lactamase in Klebsiella pneumoniae in Spain. Antimicrob Agents Chemother 55:4398–4401 [View Article][PubMed]
    [Google Scholar]
  14. Poirel L., Al Maskari Z., Al Rashdi F., Bernabeu S., Nordmann P. 2011; NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman. J Antimicrob Chemother 66:304–306 [View Article][PubMed]
    [Google Scholar]
  15. Sánchez-Romero I., Asensio A., Oteo J., Muñoz-Algarra M., Isidoro B., Vindel A., Alvarez-Avello J., Balandín-Moreno B., Cuevas O. other authors 2012; Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome. Antimicrob Agents Chemother 56:420–427 [View Article][PubMed]
    [Google Scholar]
  16. Sidjabat H., Nimmo G. R., Walsh T. R., Binotto E., Htin A., Hayashi Y., Li J., Nation R. L., George N., Paterson D. L. 2011; Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi metallo-β-lactamase. Clin Infect Dis 52:481–484 [View Article][PubMed]
    [Google Scholar]
  17. Solé M., Pitart C., Roca I., Fàbrega A., Salvador P., Muñoz L., Oliveira I., Gascón J., Marco F., Vila J. 2011; First description of an Escherichia coli strain producing NDM-1 carbapenemase in Spain. Antimicrob Agents Chemother 55:4402–4404 [View Article][PubMed]
    [Google Scholar]
  18. Struelens M. J., Monnet D. L., Magiorakos A. P., Santos O’Connor F., Giesecke J.European NDM-1 Survey Participants 2010; New Delhi metallo-beta-lactamase 1-producing Enterobacteriaceae: emergence and response in Europe. Euro Surveill 15:1971[PubMed]
    [Google Scholar]
  19. Tato M., Morosini M., García L., Albertí S., Coque M. T., Cantón R. 2010; Carbapenem heteroresistance in VIM-1-producing Klebsiella pneumoniae isolates belonging to the same clone: consequences for routine susceptibility testing. J Clin Microbiol 48:4089–4093 [View Article][PubMed]
    [Google Scholar]
  20. Yong D., Toleman M. A., Giske C. G., Cho H. S., Sundman K., Lee K., Walsh T. R. 2009; Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53:5046–5054 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.043190-0
Loading
/content/journal/jmm/10.1099/jmm.0.043190-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error