1887

Journal of Medical Microbiology logo

Volume 61, Issue 12

Multidrug-resistant group on the rise in Europe? Free

Abstract

We report a case of multidrug-resistance (MDR) in a strain of from a blood culture and abdominal fluid in a Danish patient. The patient had not been travelling for several years and had not received antibiotics prior to the present case. We also summarize the cases that have been reported to date of MDR group in Europe. As far as we know, a case like this with MDR has not been described in Scandinavia before.

  • Received:
  • Accepted:
  • Published Online:
© 2012 SGM
Loading

Article metrics loading...

/content/journal/jmm/10.1099/jmm.0.049825-0
2012-12-01
2024-04-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/61/12/1784.html?itemId=/content/journal/jmm/10.1099/jmm.0.049825-0&mimeType=html&fmt=ahah

References

  1. Bartha N. A., Sóki J., Urbán E., Nagy E. 2011; Investigation of the prevalence of tetQ, tetX and tetX1 genes in Bacteroides strains with elevated tigecycline minimum inhibitory concentrations. Int J Antimicrob Agents 38:522–525 [View Article][PubMed]
     [Google Scholar]
  2. Dubreuil L., Odou M. F. 2010; Anaerobic bacteria and antibiotics: what kind of unexpected resistance could I find in my laboratory tomorrow?. Anaerobe 16:555–559 [View Article][PubMed]
     [Google Scholar]
  3. García N., Gutiérrez G., Lorenzo M., Vadillo S., Píriz S., Quesada A. 2009; Gene context and DNA rearrangements in the carbapenemase locus of division II strains of Bacteroides fragilis. Antimicrob Agents Chemother 53:2677–2678 [View Article][PubMed]
     [Google Scholar]
  4. Kato N., Yamazoe K., Han C.-G., Ohtsubo E. 2003; New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains. Antimicrob Agents Chemother 47:979–985 [View Article][PubMed]
     [Google Scholar]
  5. Katsandri A., Papaparaskevas J., Pantazatou A., Petrikkos G. L., Thomopoulos G., Houhoula D. P., Avlamis A. 2006; Two cases of infections due to multidrug-resistant Bacteroides fragilis group strains. J Clin Microbiol 44:3465–3467 [View Article][PubMed]
     [Google Scholar]
  6. Löfmark S., Fang H., Hedberg M., Edlund C. 2005; Inducible metronidazole resistance and nim genes in clinical Bacteroides fragilis group isolates. Antimicrob Agents Chemother 49:1253–1256 [View Article][PubMed]
     [Google Scholar]
  7. Löfmark S., Edlund C., Nord C. E. 2010; Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis 50:Suppl. 1S16–S23 [View Article][PubMed]
     [Google Scholar]
  8. Nagy E. 2010; Anaerobic infections: update on treatment considerations. Drugs 70:841–858 [View Article][PubMed]
     [Google Scholar]
  9. Nagy E., Sóki J., Urban E., Szöke I., Fodor E., Edwards R. 2001; Occurrence of metronidazole and imipenem resistance among Bacteroides fragilis group clinical isolates in Hungary. Acta Biol Hung 52:271–280 [View Article][PubMed]
     [Google Scholar]
  10. Nagy E., Urbán E., Nord C. E.ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria 2011; Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience. Clin Microbiol Infect 17:371–379 [View Article][PubMed]
     [Google Scholar]
  11. Nguyen M. H., Yu V. L., Morris A. J., McDermott L., Wagener M. W., Harrell L., Snydman D. R. 2000; Antimicrobial resistance and clinical outcome of Bacteroides bacteremia: findings of a multicenter prospective observational trial. Clin Infect Dis 30:870–876 [View Article][PubMed]
     [Google Scholar]
  12. Podglajen I., Breuil J., Bordon F., Gutmann L., Collatz E. 1992; A silent carbapenemase gene in strains of Bacteroides fragilis can be expressed after a one-step mutation. FEMS Microbiol Lett 70:21–29 [View Article][PubMed]
     [Google Scholar]
  13. Podglajen I., Breuil J., Collatz E. 1994; Insertion of a novel DNA sequence, 1S1186, upstream of the silent carbapenemase gene cfiA, promotes expression of carbapenem resistance in clinical isolates of Bacteroides fragilis. Mol Microbiol 12:105–114 [View Article][PubMed]
     [Google Scholar]
  14. Pumbwe L., Wareham D. W., Aduse-Opoku J., Brazier J. S., Wexler H. M. 2007; Genetic analysis of mechanisms of multidrug resistance in a clinical isolate of Bacteroides fragilis. Clin Microbiol Infect 13:183–189 [View Article][PubMed]
     [Google Scholar]
  15. Roh K. H., Kim S., Kim C.-K., Yum J. H., Kim M. S., Yong D., Jeong S. H., Lee K., Kim J. M., Chong Y. 2010; New cfiA variant and novel insertion sequence elements in carbapenem-resistant Bacteroides fragilis isolates from Korea. Diagn Microbiol Infect Dis 66:343–348 [View Article][PubMed]
     [Google Scholar]
  16. Rotimi V. O., Khoursheed M., Brazier J. S., Jamal W. Y., Khodakhast F. B. 1999; Bacteroides species highly resistant to metronidazole: an emerging clinical problem?. Clin Microbiol Infect 5:166–169 [View Article][PubMed]
     [Google Scholar]
  17. Seifert H., Dalhoff A.PRISMA Study Group 2010; German multicentre survey of the antibiotic susceptibility of Bacteroides fragilis group and Prevotella species isolated from intra-abdominal infections: results from the PRISMA study. J Antimicrob Chemother 65:2405–2410 [View Article][PubMed]
     [Google Scholar]
  18. Snydman D. R., Jacobus N. V., McDermott L. A., Golan Y., Goldstein E. J. C., Harrell L., Jenkins S., Newton D., Pierson C. other authors 2011; Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006–2009. Anaerobe 17:147–151 [View Article][PubMed]
     [Google Scholar]
  19. Sóki J., Fodor E., Hecht D. W., Edwards R., Rotimi V. O., Kerekes I., Urbán E., Nagy E. 2004; Molecular characterization of imipenem-resistant, cfiA-positive Bacteroides fragilis isolates from the USA, Hungary and Kuwait. J Med Microbiol 53:413–419 [View Article][PubMed]
     [Google Scholar]
  20. Sóki J., Gal M., Brazier J. S., Rotimi V. O., Urbán E., Nagy E., Duerden B. I. 2006; Molecular investigation of genetic elements contributing to metronidazole resistance in Bacteroides strains. J Antimicrob Chemother 57:212–220 [View Article][PubMed]
     [Google Scholar]
  21. Steffens L. S., Nicholson S., Paul L. V., Nord C. E., Patrick S., Abratt V. R. 2010; Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole. Res Microbiol 161:346–354 [View Article][PubMed]
     [Google Scholar]
  22. Stubbs S. L. J., Brazier J. S., Talbot P. R., Duerden B. I. 2000; PCR-restriction fragment length polymorphism analysis for identification of Bacteroides spp. and characterization of nitroimidazole resistance genes. J Clin Microbiol 38:3209–3213[PubMed]
     [Google Scholar]
  23. Toprak N. U., Uzunkaya O. D., Sóki J., Soyletir G. 2012; Susceptibility profiles and resistance genes for carbapenems (cfiA) and metronidazole (nim) among Bacteroides species in a Turkish University Hospital. Anaerobe 18:169–171 [View Article][PubMed]
     [Google Scholar]
  24. Trinh S., Haggoud A., Reysset G., Sebald M. 1995; Plasmids pIP419 and pIP421 from Bacteroides: 5-nitroimidazole resistance genes and their upstream insertion sequence elements. Microbiology 141:927–935 [View Article][PubMed]
     [Google Scholar]
  25. Turner P., Edwards R., Weston V., Gazis A., Ispahani P., Greenwood D. 1995; Simultaneous resistance to metronidazole, co-amoxiclav, and imipenem in clinical isolate of Bacteroides fragilis. Lancet 345:1275–1277 [View Article][PubMed]
     [Google Scholar]
  26. Walsh T. R., Bolmström A., Qwärnström A., Gales A. 2002; Evaluation of a new Etest for detecting metallo-β-lactamases in routine clinical testing. J Clin Microbiol 40:2755–2759 [View Article][PubMed]
     [Google Scholar]
  27. Wareham D. W., Wilks M., Ahmmed D., Brazier J. S., Millar M. 2005; Anaerobic sepsis due to multidrug-resistant Bacteroides fragilis: microbiological cure and clinical response with linezolid therapy. Clin Infect Dis 40:e67–e68 [View Article][PubMed]
     [Google Scholar]
  28. Wybo I., De Bel A., Soetens O., Echahidi F., Vandoorslaer K., Van Cauwenbergh M., Piérard D. 2011; Differentiation of cfiA-negative and cfiA-positive Bacteroides fragilis isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry. J Clin Microbiol 49:1961–1964 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/jmm.0.049825-0
Loading
Multidrug-resistant Bacteroides fragilis group on the rise in Europe?
J. Med. Microbiol. 61, 1784 (2012); https://doi.org/10.1099/jmm.0.049825-0
/content/journal/jmm/10.1099/jmm.0.049825-0
/content/journal/jmm/10.1099/jmm.0.049825-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error