Antifungal properties of 5-hydroxytryptamine (serotonin) against Candida species in vitro
Lass-Flörl, Cornelia and Fuchs, Dietmar and Ledochowski, Maximilian and Speth, Cornelia and Dierich, Manfred P. and Würzner, Reinhard,, 52, 169-171 (2003),
doi = https://doi.org/10.1099/jmm.0.04987-0,
publicationName = Microbiology Society,
issn = 0022-2615,
abstract= In this study the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of 5-hydroxytryptamine (5 HT, serotonin) against clinical isolates of Candida albicans (n = 11), Candida glabrata (n = 9), Candida tropicalis (n = 10) and Candida parapsilosis (ATCC 22019) using a broth microdilution test were investigated. In addition, it was examined whether delayed regrowth as a post-antifungal effect results following short exposure to 5 HT. 5 HT showed antifungal activity towards all isolates of Candida spp. The isolates yielded comparable MIC and MFC values of 5 HT in the range 0.91–7.34 mM and 1.83–14.68 mM, respectively. A lag in regrowth was dependent on the concentration tested. Treatment for 3 h at concentrations of 5 HT below and equipotent to the MFC resulted in a delayed regrowth of 8–12 h for isolates of Candida spp. In conclusion, these in vitro studies clearly demonstrate antifungal effects of 5 HT. Identifying the mode of action could be of great help in developing and researching new antifungal drugs.,
language=,
type=