1887

Abstract

The aim of the present study was to develop a reproducible porcine infection model with . The influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. Furthermore, the synergistic effect of additional bacteria ( O141, or a mixture of , a field isolate of and ) was studied. Experimental infection resulted in an increase in the serum concentrations of the acute-phase proteins serum amyloid A and haptoglobin and the percentages of neutrophils and monocytes. These alterations were specifically related to haemorrhagic diarrhoea. Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals. If the pigs were fed soybean meal, kept in single pens and circulated between the pens, five out of nine developed disease.

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2004-04-01
2024-04-19
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References

  1. Albassam M. A., Olander H. J., Thacker H. L., Turek J. J. 1985; Ultrastructural characterization of colonic lesions in pigs inoculated with Treponema hyodysenteriae . Can J Comp Med 49:384–390
    [Google Scholar]
  2. Blaha T., Günther H., Flossmann K.-D., Erler W. 1984; Der epizootische Grundvorgang der Schweinedysenterie. Zentbl Veterinärmed B 31:451–465 (in German
    [Google Scholar]
  3. Canh T. T., Sutton A. L., Aarnink A. J. A., Verstegen M. W. A., Schrama J. W., Bakker G. C. M. 1998; Dietary carbohydrates alter the fecal composition and pH and the ammonia emission from slurry of growing pigs. J Anim Sci 76:1887–1895
    [Google Scholar]
  4. Dewey C. E. 1993; Ration-induced diarrhea in grower pigs. J Swine Health Prod 1:16–21
    [Google Scholar]
  5. Dréau D., Lallés J. P., Philouze-Romé V., Toullec R., Salmon H. 1994; Local and systemic immune responses to soybean protein ingestion in early-weaned pigs. J Anim Sci 72:2090–2098
    [Google Scholar]
  6. Dréau D., Lallés J. P., Toullec R., Salmon H. 1995; B and T lymphocytes are enhanced in the gut of piglets fed heat-treated soyabean proteins. Vet Immunol Immunopathol 47:69–79 [CrossRef]
    [Google Scholar]
  7. Durmic Z., Pethick D. W., Pluske J. R., Hampson D. J. 1998; Changes in bacterial populations in the colon of pigs fed different sources of dietary fibre, and the development of swine dysentery after experimental infection. J Appl Microbiol 85:574–582 [CrossRef]
    [Google Scholar]
  8. Eriksen L., Andersen S. 1970; Undersögelser over eksperimentelt fremkaldt svinedysenteri (experimental swine dysentery). Nord Vetmed 22:161–173 (in Norwegian
    [Google Scholar]
  9. Fellström C., Gunnarsson A. 1995; Phenotypical characterisation of intestinal spirochaetes isolated from pigs. Res Vet Sci 59:1–4 [CrossRef]
    [Google Scholar]
  10. Galvin J. E., Harris D. L., Wannemuehler M. J. 1997; Prevention and control of intestinal spirochaetal disease: immunological and pharmacological mechanisms. In Intestinal Spirochaetes in Domestic Animals and Humans pp 343–374 Edited by Hampson D. J., Stanton T. B. Wallingford, UK: CAB International;
    [Google Scholar]
  11. Gruys E., Obwolo M. J., Toussaint M. J. M. 1994; Diagnostic significance of the major acute phase proteins in veterinary clinical chemistry: a review. Vet Bull 64:1009–1018
    [Google Scholar]
  12. Hampson D. J., Cutler R., Lee B. J. 1992; Virulent Serpulina hyodysenteriae from a pig in a herd free of clinical swine dysentery. Vet Rec 131:318–319 [CrossRef]
    [Google Scholar]
  13. Harris D. L., Alexander T. J. L., Whipp S. C., Robinson I. M., Glock R. D., Matthews P. J. 1978; Swine dysentery: studies of gnotobiotic pigs inoculated with Treponema hyodysenteriae , Bacteroides vulgatus , and Fusobacterium necrophorum . J Am Vet Med Assoc 172:468–471
    [Google Scholar]
  14. Heegaard P. M. H., Klausen J., Nielsen J. P., González-Ramón N., Piñeiro M., Lampreave F., Alava M. A. 1998; The porcine acute phase response to infection with Actinobacillus pleuropneumoniae .Haptoglobin, C-reactive protein, major acute phase protein and serum amyloid A protein are sensitive indicators of infection. Comp Biochem Physiol B 119:365–373 [CrossRef]
    [Google Scholar]
  15. Higuchi H., Katoh N., Miyamoto T., Uchida E., Yuasa A., Takahashi K. 1994; Dexamethasone-induced haptoglobin release by calf liver parenchymal cells. Am J Vet Res 55:1080–1085
    [Google Scholar]
  16. Hudson M. J., Alexander T. J. L., Lysons R. J., Wellstead P. D. 1974; Swine dysentery: failure of an attenuated strain of spirochaete, given orally, to protect pigs against subsequent challenge. Br Vet J 130:37–40
    [Google Scholar]
  17. Huisman J., Jansman A. J. M. 1991; Dietary effects and some analytical aspects of antinutritional factors in peas ( Pisum sativum ), common beans ( Phaseolus vulgaris ) and soyabeans ( Glycine max L.) in monogastric farm animals. A literature review. Nutr Abstr Rev Ser B 61:901–921
    [Google Scholar]
  18. Jacobson M., Lindberg J. E., Lindberg R., Hård af Segerstad C., Wallgren P., Fellström C., Hultén C., Jensen-Waern M. 2001; Intestinal cannulation: model for study of the midgut of the pig. Comp Med 51:163–170
    [Google Scholar]
  19. Jensen T. K., Boye M., Möller K., Leser T. D., Jorsal S. E. 1998; Association of Serpulina hyodysenteriae with the colonic mucosa in experimental swine dysentery studied by fluorescent in situ hybridization. APMIS 106:1061–1068 [CrossRef]
    [Google Scholar]
  20. Jiang S.-L., Lozanski G., Samols D., Kushner I. 1995; Induction of human serum amyloid A in Hep 3B cells by IL-6 and IL-1 beta involves both transcriptional and post-transcriptional mechanisms. J Immunol 154:825–831
    [Google Scholar]
  21. Joens L. A., Whipp S. C., Glock R. D., Neussen M. E. 1983; Serotype-specific protection against Treponema hyodysenteriae infection in ligated colonic loops of pigs recovered from swine dysentery. Infect Immun 39:460–462
    [Google Scholar]
  22. Kinyon J. M., Harris D. L., Glock R. D. 1977; Enteropathogenicity of various isolates of Treponema hyodysenteriae . Infect Immun 15:638–646
    [Google Scholar]
  23. Kinyon J. M., Harris D. L., Glock R. D. 1980; Isolation of Treponema hyodysenteriae from experimentally infected pigs at various intervals post-inoculation. In Proceedings of the 6th International Pig Veterinary Society Congress p– 232 Copenhagen, Denmark:
    [Google Scholar]
  24. Kühn I., Katouli M., Lund A., Wallgren P., Möllby R. 1993; Phenotypic diversity and stability of the intestinal coliform flora in piglets during the first 3 months of age. Microb Ecol Health Dis 6:101–107 [CrossRef]
    [Google Scholar]
  25. Li D. F., Nelssen J. L., Reddy P. G., Blecha F., Klemm R., Goodband R. D. 1991; Interrelationship between hypersensitivity to soybean proteins and growth performance in early-weaned pigs. J Anim Sci 69:4062–4069
    [Google Scholar]
  26. Mackiewicz A., Speroff T., Ganapathi M. K., Kushner I. 1991; Effects of cytokine combinations on acute phase protein production in two human hepatoma cell lines. J Immunol 146:3032–3037
    [Google Scholar]
  27. Makinde M. O., Umapathy E., Akingbemi B. T., Mandisodza K. T., Skadhauge E. 1996; Effects of dietary soybean and cowpea on gut morphology and faecal composition in creep and noncreep-fed pigs. Zentbl Veterinärmed A 43:75–85 [CrossRef]
    [Google Scholar]
  28. Melin L., Mattsson S., Katouli M., Wallgren P. 2003; Development of post weaning diarrhoea in piglets.Relation to presence of Escherichia coli -strains and rotavirus. J Vet Med B 47:663–675
    [Google Scholar]
  29. Meyer R. C., Simon J., Byerly C. S. 1974a; The etiology of swine dysentery.I. Oral inoculation of germ-free swine with Treponema hyodysenteriae and Vibrio coli . Vet Pathol 11:515–526
    [Google Scholar]
  30. Meyer R. C., Simon J., Byerly C. S. 1974b; The etiology of swine dysentery.II. Effect of a known microbial flora, weaning and diet on disease production in gnotobiotic and conventional swine. Vet Pathol 11:527–534
    [Google Scholar]
  31. Meyer R. C., Simon J., Byerly C. S. 1975; The etiology of swine dysentery.III. The role of selected gram-negative obligate anaerobes. Vet Pathol 12:46–54
    [Google Scholar]
  32. Midtvedt T. 1999; Microbial functional activities. In Probiotics. Other Nutritional Factors, and Intestinal Microflora pp 79–96 Edited by Hanson L. A., Yolken R. H. Philadelphia, PA: Lippincott-Raven;
    [Google Scholar]
  33. Moreng N. T., Quarles C. L., Fagerberg D. J., Moeller D. J. 1980; Pathogenesis and lesions of swine dysentery induced by artificial methods in early weaned pigs. Vet Med Small Anim Clin 75:1841–1844
    [Google Scholar]
  34. Nabuurs M. J. A. 1986; Thermostable factor(s) in soya producing a net excess of secretion in the ligated gut test in pigs. Vet Res Commun 10:399–405 [CrossRef]
    [Google Scholar]
  35. Nabuurs M. J. A., van Zijderveld F. G., de Leeuw P. W. 1993; Clinical and microbiological field studies in The Netherlands of diarrhoea in pigs at weaning. Res Vet Sci 55:70–77 [CrossRef]
    [Google Scholar]
  36. Neef N. A., Lysons R. J., Trott D. J., Hampson D. J., Jones P. W., Morgan J. H. 1994a; Pathogenicity of porcine intestinal spirochetes in gnotobiotic pigs. Infect Immun 62:2395–2403
    [Google Scholar]
  37. Neef N. A., McOrist S., Lysons R. J., Bland A. P., Miller B. G. 1994b; Development of large intestinal attaching and effacing lesions in pigs in association with the feeding of a particular diet. Infect Immun 62:4325–4332
    [Google Scholar]
  38. Olson L. D. 1974; Clinical and pathological observations on the experimental passage of swine dysentery. Can J Comp Med 38:7–13
    [Google Scholar]
  39. Pluske J. R., Siba P. M., Pethick D. W., Durmic Z., Mullan B. P., Hampson D. J. 1996; The incidence of swine dysentery in pigs can be reduced by feeding diets that limit the amount of fermentable substrate entering the large intestine. J Nutr 126:2920–2933
    [Google Scholar]
  40. Raynaud J. P., Brunault G., Philippe J. 1980; Swine dysentery.Comparison of experimental diseases produced by infection with colonic mucosa or with Treponema hyodysenteriae , French strains, and of ‘natural’ disease. Ann Rech Vét 11:68–87
    [Google Scholar]
  41. Reddy N. R., Pierson M. D. 1994; Reduction in antinutritional and toxic components in plant foods by fermentation. Food Res Int 27:281–290 [CrossRef]
    [Google Scholar]
  42. Rees A. S., Lysons R. J., Stokes C. R., Bourne F. J. 1989; Antibody production by the pig colon during infection with Treponema hyodysenteriae . Res Vet Sci 47:263–269
    [Google Scholar]
  43. Savage D. C. 1980; Colonization by and survival of pathogenic bacteria on intestinal mucosal surfaces. In Adsorption of Microorganisms to Surfaces pp 175–206 Edited by Bitton B., Marshall K. C. New York: Wiley;
    [Google Scholar]
  44. Siba P. M., Pethick D. W., Hampson D. J. 1996; Pigs experimentally infected with Serpulina hyodysenteriae can be protected from developing swine dysentery by feeding them a highly digestible diet. Epidemiol Infect 116:207–216 [CrossRef]
    [Google Scholar]
  45. Taylor D. J., Alexander T. J. L. 1971; The production of dysentery in swine by feeding cultures containing a spirochaete. Br Vet J 127:58–61
    [Google Scholar]
  46. Uhlar C. M., Whitehead A. S. 1999; Serum amyloid A, the major vertebrate acute-phase reactant. Eur J Biochem 265:501–523 [CrossRef]
    [Google Scholar]
  47. Whipp S. C., Robinson I. M., Harris D. L., Glock R. D., Matthews P. J., Alexander T. J. L. 1979; Pathogenic synergism between Treponema hyodysenteriae and other selected anaerobes in gnotobiotic pigs. Infect Immun 26:1042–1047
    [Google Scholar]
  48. Whiting R. A., Doyle L. P., Spray R. S. 1937; Swine dysentery. Bulletin 257:1–15
    [Google Scholar]
  49. Wilcock B. P., Olander H. J. 1979; Studies on the pathogenesis of swine dysentery.I. Characterization of the lesions in colons and colonic segments inoculated with pure cultures or colonic content containing Treponema hyodysenteriae . Vet Pathol 16:450–465
    [Google Scholar]
  50. Wright J. C., Wilt G. R., Reed R. B., Powe T. A. 1989; Use of an enzyme-linked immunosorbent assay for detection of Treponema hyodysenteriae infection in swine. J Clin Microbiol 27:411–416
    [Google Scholar]
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