1887

Abstract

Historically, enteropathogenic (EPEC) are a well-known cause of outbreaks of infantile diarrhoea associated with morbidity and mortality in England. The aim of this study was to provide an update on the microbiology and epidemiology of strains of EPEC in England between 2010 and 2012. A wide range of serogroups were identified, with the most common being O145, O49 and O157. Few isolates (9 %) had additional virulence factors (specifically , and genes) and the majority were classified as atypical EPEC. The majority of cases (86 %) were among children. This included a significantly higher percentage (17.4 %) of cases aged 0–12 months when compared with cases of other common gastrointestinal pathogens (<0.001). No outbreaks were reported during this period; however, the data indicated that EPEC are still an important cause of sporadic cases of infantile diarrhoea in England.

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2013-10-01
2024-03-28
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References

  1. Afset J. E., Bevanger L., Romundstad P., Bergh K. 2004; Association of atypical enteropathogenic Escherichia coli (EPEC) with prolonged diarrhoea. J Med Microbiol 53:1137–1144 [View Article][PubMed]
    [Google Scholar]
  2. Arbeloa A., Blanco M., Moreira F. C., Bulgin R., López C., Dahbi G., Blanco J. E., Mora A., Alonso M. P. other authors 2009; Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli.. J Med Microbiol 58:988–995 [View Article][PubMed]
    [Google Scholar]
  3. Bielaszewska M., Middendorf B., Köck R., Friedrich A. W., Fruth A., Karch H., Schmidt M. A., Mellmann A. 2008; Shiga toxin-negative attaching and effacing Escherichia coli: distinct clinical associations with bacterial phylogeny and virulence traits and inferred in-host pathogen evolution. Clin Infect Dis 47:208–217 [View Article][PubMed]
    [Google Scholar]
  4. Bray J. 1945; Isolation of antigenically homogenous strains of Bact. coli neapolitanum from summer diarrhoea in infants. J Pathol Bacteriol 57:239–247 [View Article]
    [Google Scholar]
  5. Bulgin R., Arbeloa A., Goulding D., Dougan G., Crepin V. F., Raymond B., Frankel G. 2009; The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals. PLoS Pathog 5:e1000683 [View Article][PubMed]
    [Google Scholar]
  6. Chen H. D., Frankel G. 2005; Enteropathogenic Escherichia coli: unravelling pathogenesis. FEMS Microbiol Rev 29:83–98 [View Article][PubMed]
    [Google Scholar]
  7. Clarke S. C., Haigh R. D., Freestone P. P., Williams P. H. 2003; Virulence of enteropathogenic Escherichia coli, a global pathogen. Clin Microbiol Rev 16:365–378 [View Article][PubMed]
    [Google Scholar]
  8. Cravioto A., Gross R. J., Scotland S. M., Rowe B. 1979; An adhesive factor found in strains of Escherichia coli belonging to the traditional infantile enteropathogenic serotypes. Curr Microbiol 3:95–99 [View Article]
    [Google Scholar]
  9. Hernandes R. T., Elias W. P., Vieira M. A., Gomes T. A. 2009; An overview of atypical enteropathogenic Escherichia coli.. FEMS Microbiol Lett 297:137–149 [View Article][PubMed]
    [Google Scholar]
  10. Jenkins C., Lawson A. J., Cheasty T., Willshaw G. A., Wright P., Dougan G., Frankel G., Smith H. R. 2003; Subtyping intimin genes from enteropathogenic Escherichia coli associated with outbreaks and sporadic cases in the United Kingdom and Eire. Mol Cell Probes 17:149–156 [View Article][PubMed]
    [Google Scholar]
  11. Jenkins C., Smith H. R., Lawson A. J., Willshaw G. A., Cheasty T., Wheeler J. G., Tompkins D. S. 2006; Serotypes, intimin subtypes, and antimicrobial resistance patterns of atypical enteropathogenic Escherichia coli isolated in England from 1993 to 1996. Eur J Clin Microbiol Infect Dis 25:19–24 [View Article][PubMed]
    [Google Scholar]
  12. Jenkins C., Lawson A. J., Cheasty T., Willshaw G. A. 2012; Assessment of a real-time PCR for the detection and characterization of verocytotoxigenic Escherichia coli.. J Med Microbiol 61:1082–1085 [View Article][PubMed]
    [Google Scholar]
  13. Kaper J. B. 1998; EPEC delivers the goods. Trends Microbiol 6:169–173. [View Article][PubMed]
    [Google Scholar]
  14. McDaniel T. K., Jarvis K. G., Donnenberg M. S., Kaper J. B. 1995; A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens. Proc Natl Acad Sci U S A 92:1664–1668 [View Article][PubMed]
    [Google Scholar]
  15. Ochoa T. J., Contreras C. A. 2011; Enteropathogenic Escherichia coli infection in children. Curr Opin Infect Dis 24:478–483 [View Article][PubMed]
    [Google Scholar]
  16. Prager R., Fruth A., Siewert U., Strutz U., Tschäpe H. 2009; Escherichia coli encoding Shiga toxin 2f as an emerging human pathogen. Int J Med Microbiol 299:343–353 [View Article][PubMed]
    [Google Scholar]
  17. Scheutz F., Teel L. D., Beutin L., Piérard D., Buvens G., Karch H., Mellmann A., Caprioli A., Tozzoli R. other authors 2012; Multicenter evaluation of a sequence-based protocol for subtyping Shiga toxins and standardizing Stx nomenclature. J Clin Microbiol 50:2951–2963 [View Article][PubMed]
    [Google Scholar]
  18. Smith H. R., Scotland S. M., Cheasty T., Willshaw G. A., Rowe B. 1996; Enteropathogenic Escherichia coli infections in the United Kingdom. Rev Microbiol Sao Paulo 27:Suppl. 145–49
    [Google Scholar]
  19. Taylor J. 1970; Infectious infantile enteritis, yesterday and today. Proc R Soc Med 63:1297–1301[PubMed]
    [Google Scholar]
  20. Tompkins D. S., Hudson M. J., Smith H. R., Eglin R. P., Wheeler J. G., Brett M. M., Owen R. J., Brazier J. S., Cumberland P. other authors 1999; A study of infectious intestinal disease in England: microbiological findings in cases and controls. Commun Dis Public Health 2:108–113[PubMed]
    [Google Scholar]
  21. Trabulsi L. R., Keller R., Tardelli Gomes T. A. 2002; Typical and atypical enteropathogenic Escherichia coli. Emerg Infect Dis 8:508–513 [View Article][PubMed]
    [Google Scholar]
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