1887

Abstract

The roles of inflammation and/or infection of the male accessory sex glands are very important for the potential effects that these conditions may have on male fertility. The clinical andrologist should be aware of the pathophysiological role of the main determinants of sperm damage when these conditions occur, in particular, seminal leukocytes, oxidative stress and cytokines. In addition, it is important to have a good knowledge of the methodologies to be used in clinical practice. This article summarizes the methods used to look for and to identify the micro-organisms responsible for male urogenital tract infections. These include sperm culture, urine culture, urethral swabbing, the Meares–Stamey test and balanopreputial swabbing. Finally, we discuss the role of human papilloma virus infection in male infertility.

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2014-01-01
2024-04-19
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References

  1. Aitken R. J., Clarkson J. S., Hargreave T. B., Irvine D. S., Wu F. C. 1989; Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl 10:214–220[PubMed]
    [Google Scholar]
  2. Aitken R. J., Gordon E., Harkiss D., Twigg J. P., Milne P., Jennings Z., Irvine D. S. 1998; Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59:1037–1046 [View Article][PubMed]
    [Google Scholar]
  3. Aljabari B., Calogero A. E., Perdichizzi A., Vicari E., Karaki R., Lahloub T., Zatari R., El-Abed K., Nicoletti F. other authors 2007; Imbalance in seminal fluid MIF indicates male infertility. Mol Med 13:199–202 [View Article][PubMed]
    [Google Scholar]
  4. Allam J. P., Fronhoffs F., Fathy A., Novak N., Oltermann I., Bieber T., Schuppe H. C., Haidl G. 2008; High percentage of apoptotic spermatozoa in ejaculates from men with chronic genital tract inflammation. Andrologia 40:329–334 [View Article][PubMed]
    [Google Scholar]
  5. Askienazy-Elbhar M. 2005; [Male genital tract infection: the point of view of the bacteriologist]. Gynecol Obstet Fertil 33:691–697 (in French) [View Article][PubMed]
    [Google Scholar]
  6. Aydemir B., Onaran I., Kiziler A. R., Alici B., Akyolcu M. C. 2008; The influence of oxidative damage on viscosity of seminal fluid in infertile men. J Androl 29:41–46 [View Article][PubMed]
    [Google Scholar]
  7. Barroso G., Morshedi M., Oehninger S. 2000; Analysis of DNA fragmentation, plasma membrane translocation of phosphatidylserine and oxidative stress in human spermatozoa. Hum Reprod 15:1338–1344 [View Article][PubMed]
    [Google Scholar]
  8. Bian S. L., Jin H. B., Wang S. Z., Zhang H. F., Gu C. R., Zhang W., Yu X. G. 2007; [Effects of interferon-gamma and tumor necrosis factor-alpha on the fertilizing capacity of human sperm and their mechanisms]. Zhonghua Nan Ke Xue 13:681–684 (in Chinese) [PubMed]
    [Google Scholar]
  9. Boitrelle F., Robin G., Lefebvre C., Bailly M., Selva J., Courcol R., Lornage J., Albert M. 2012; [Bacteriospermia in Assisted Reproductive Techniques: effects of bacteria on spermatozoa and seminal plasma, diagnosis and treatment]. Gynecol Obstet Fertil 40:226–234 (in French) [View Article][PubMed]
    [Google Scholar]
  10. Budía A., Luis Palmero J., Broseta E., Tejadillos S., Benedicto A., Queipo J. A., Gobernado M., Fernando Jiménez Cruz J. 2006; Value of semen culture in the diagnosis of chronic bacterial prostatitis: a simplified method. Scand J Urol Nephrol 40:326–331 [View Article][PubMed]
    [Google Scholar]
  11. Camejo M. I., Segnini A., Proverbio F. 2001; Interleukin-6 (IL-6) in seminal plasma of infertile men, and lipid peroxidation of their sperm. Arch Androl 47:97–101 [View Article][PubMed]
    [Google Scholar]
  12. Carli C., Leclerc P., Metz C. N., Akoum A. 2007; Direct effect of macrophage migration inhibitory factor on sperm function: possible involvement in endometriosis-associated infertility. Fertil Steril 88:Suppl1240–1247 [View Article][PubMed]
    [Google Scholar]
  13. Comhaire F., Verschraegen G., Vermeulen L. 1980; Diagnosis of accessory gland infection and its possible role in male infertility. Int J Androl 3:32–45 [View Article][PubMed]
    [Google Scholar]
  14. Comhaire F. H., Vermeulen L., Pieters O. 1989; Study of the accuracy of physical and biochemical markers in semen to detect infectious dysfunction of the accessory sex glands. J Androl 10:50–53[PubMed]
    [Google Scholar]
  15. Comhaire F. H., Mahmoud A. M. A., Depuydt C. E., Zalata A. A., Christophe A. B. 1999; Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist’s viewpoint. Hum Reprod Update 5:393–398 [View Article][PubMed]
    [Google Scholar]
  16. Cooper T. G., Weidner W., Nieschlag E. 1990; The influence of inflammation of the human male genital tract on secretion of the seminal markers alpha-glucosidase, glycerophosphocholine, carnitine, fructose and citric acid. Int J Androl 13:329–336 [View Article][PubMed]
    [Google Scholar]
  17. De Francesco M. A., Negrini R., Ravizzola G., Galli P., Manca N. 2011; Bacterial species present in the lower male genital tract: a five-year retrospective study. Eur J Contracept Reprod Health Care 16:47–53 [View Article][PubMed]
    [Google Scholar]
  18. Dimitrov D. G., Petrovská M. 1996; Effects of products of activated immune cells and recombinant cytokines on spontaneous and ionophore-induced acrosome reaction. Am J Reprod Immunol 36:150–156 [View Article][PubMed]
    [Google Scholar]
  19. Dousset B., Hussenet F., Daudin M., Bujan L., Foliguet B., Nabet P. 1997; Seminal cytokine concentrations (IL-1beta, IL-2, IL-6, sR IL-2, sR IL-6), semen parameters and blood hormonal status in male infertility. Hum Reprod 12:1476–1479 [View Article][PubMed]
    [Google Scholar]
  20. Eggert-Kruse W., Boit R., Rohr G., Aufenanger J., Hund M., Strowitzki T. 2001; Relationship of seminal plasma interleukin (IL) -8 and IL-6 with semen quality. Hum Reprod 16:517–528 [View Article][PubMed]
    [Google Scholar]
  21. Estrada L. S., Champion H. C., Wang R., Rajasekaran M., Hellstrom W. J., Aggarwal B., Sikka S. C. 1997; Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. Int J Androl 20:237–242 [View Article][PubMed]
    [Google Scholar]
  22. Fedder J., Ellermann-eriksen S. 1995; Effect of cytokines on sperm motility and ionophore-stimulated acrosome reaction. Arch Androl 35:173–185 [View Article][PubMed]
    [Google Scholar]
  23. Foresta C., Pizzol D., Bertoldo A., Menegazzo M., Barzon L., Garolla A. 2011; Semen washing procedures do not eliminate human papilloma virus sperm infection in infertile patients. Fertil Steril 96:1077–1082 [View Article][PubMed]
    [Google Scholar]
  24. Fraczek M., Kurpisz M. 2007; Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa. J Androl 28:325–333 [View Article][PubMed]
    [Google Scholar]
  25. Fraczek M., Sanocka D., Kamieniczna M., Kurpisz M. 2008; Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions. J Androl 29:85–92 [View Article][PubMed]
    [Google Scholar]
  26. Frenette G., Légaré C., Saez F., Sullivan R. 2005; Macrophage migration inhibitory factor in the human epididymis and semen. Mol Hum Reprod 11:575–582 [View Article][PubMed]
    [Google Scholar]
  27. Garolla A., Pizzol D., Foresta C. 2011; The role of human papillomavirus on sperm function. Curr Opin Obstet Gynecol 23:232–237 [View Article][PubMed]
    [Google Scholar]
  28. Girling J. E., Hedger M. P. 2007; Toll-like receptors in the gonads and reproductive tract: emerging roles in reproductive physiology and pathology. Immunol Cell Biol 85:481–489 [View Article][PubMed]
    [Google Scholar]
  29. Griveau J. F., Lannou D. L. E. 1997; Reactive oxygen species and human spermatozoa: physiology and pathology. Int J Androl 20:61–69 [View Article][PubMed]
    [Google Scholar]
  30. Gruschwitz M. S., Brezinschek R., Brezinschek H. P. 1996; Cytokine levels in the seminal plasma of infertile males. J Androl 17:158–163[PubMed]
    [Google Scholar]
  31. Hill J. A., Haimovici F., Politch J. A., Anderson D. J. 1987; Effects of soluble products of activated lymphocytes and macrophages (lymphokines and monokines) on human sperm motion parameters. Fertil Steril 47:460–465[PubMed]
    [Google Scholar]
  32. Hill J. A., Cohen J., Anderson D. J. 1989; The effects of lymphokines and monokines on human sperm fertilizing ability in the zona-free hamster egg penetration test. Am J Obstet Gynecol 160:1154–1159 [View Article][PubMed]
    [Google Scholar]
  33. Horner P. J., Taylor-Robinson D. 2011; Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis. Sex Transm Infect 87:38–40 [View Article][PubMed]
    [Google Scholar]
  34. Hussenet F., Dousset B., Cordonnier J. L., Jacob C., Foliguet B., Grignon G., Nabet P. 1993; Tumour necrosis factor alpha and interleukin 2 in normal and infected human seminal fluid. Hum Reprod 8:409–411[PubMed]
    [Google Scholar]
  35. Isemberg H. D. (editor) ( 1998 Essential Procedures for Clinical Microbiology Washington, DC: American Society for Microbiology;
    [Google Scholar]
  36. Jensen I. P., Fogh H., Prag J. 2003; Diagnosis of Chlamydia trachomatis infections in a sexually transmitted disease clinic: evaluation of a urine sample tested by enzyme immunoassay and polymerase chain reaction in comparison with a cervical and/or a urethral swab tested by culture and polymerase chain reaction. Clin Microbiol Infect 9:194–201 [View Article][PubMed]
    [Google Scholar]
  37. Koçak I., Yenisey C., Dündar M., Okyay P., Serter M. 2002; Relationship between seminal plasma interleukin-6 and tumor necrosis factor alpha levels with semen parameters in fertile and infertile men. Urol Res 30:263–267 [View Article][PubMed]
    [Google Scholar]
  38. Krieger J. N., Nyberg L. Jr, Nickel J. C. 1999; NIH consensus definition and classification of prostatitis. JAMA 282:236–237 [View Article][PubMed]
    [Google Scholar]
  39. La Vignera S., Calogero A. E., Arancio A., Castiglione R., De Grande G., Vicari E. 2008; Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia. Asian J Androl 10:731–740 [View Article][PubMed]
    [Google Scholar]
  40. La Vignera S., Vicari E., Condorelli R. A., D’Agata R., Calogero A. E. 2011; Male accessory gland infection and sperm parameters (review). Int J Androl 34:e330–e347 [View Article][PubMed]
    [Google Scholar]
  41. La Vignera S., Condorelli R., Vicari E., D’Agata R., Calogero A. E. 2012a; High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia 44:Suppl 1438–446 [View Article][PubMed]
    [Google Scholar]
  42. La Vignera S., Calogero A. E., Condorelli R. A., Vicari L. O., Catanuso M., D’Agata R., Vicari E. 2012b; Ultrasonographic evaluation of patients with male accessory gland infection. Andrologia 44:Suppl 126–31 [View Article][PubMed]
    [Google Scholar]
  43. La Vignera S., Condorelli R. A., Calogero A. E., Bellanca S., Salmeri M., Vicari E. 2012c; Persistence of ultrasound alterations after antibiotic treatment with levofloxacin in patients with male accessory gland infection. Asian J Androl 14:879–883 [View Article][PubMed]
    [Google Scholar]
  44. Lampiao F., du Plessis S. S. 2008; TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online 17:628–631 [View Article][PubMed]
    [Google Scholar]
  45. Lampiao F., du Plessis S. S. 2009; Effects of tumour necrosis factor alpha and interleukin-6 on progesterone and calcium ionophore-induced acrosome reaction. Int J Androl 32:274–277 [View Article][PubMed]
    [Google Scholar]
  46. Lanzafame F. M., La Vignera S., Vicari E., Calogero A. E. 2009; Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online 19:638–659 [View Article][PubMed]
    [Google Scholar]
  47. Leterrier M., Fréour T., Guillouzouic A., Juvin M. E., Barriere P., Reynaud A., Corvec S. 2011; Semen cultures analysis: retrospective study during a 6-year period and interest in the management of infertility. Eur J Clin Microbiol Infect Dis 30:401–406 [View Article][PubMed]
    [Google Scholar]
  48. Letkiewicz S., Międzybrodzki R., Kłak M., Jończyk E., Weber-Dąbrowska B., Górski A. 2010; The perspectives of the application of phage therapy in chronic bacterial prostatitis. FEMS Immunol Med Microbiol 60:99–112 [View Article][PubMed]
    [Google Scholar]
  49. Lewis S. E. M., Donnelly E. T., Sterling E. S. L., Kennedy M. S., Thompson W., Chakravarthy U. 1996; Nitric oxide synthase and nitrite production in human spermatozoa: evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod 2:873–878 [View Article][PubMed]
    [Google Scholar]
  50. Lipperheide V., Andraka L., Pontón J., Quindós G. 1993; Evaluation of the albicans IDR plate method for the rapid identification of Candida albicans. Mycoses 36:417–420 [View Article][PubMed]
    [Google Scholar]
  51. Lotti F., Maggi M. 2013; Interleukin 8 and the male genital tract. J Reprod Immunol [Epub ahead of print] [View Article][PubMed]
    [Google Scholar]
  52. Lotti F., Corona G., Mancini M., Filimberti E., Degli Innocenti S., Colpi G. M., Baldi E., Noci I., Forti G. other authors 2011; Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility. Int J Androl 34:600–613 [View Article][PubMed]
    [Google Scholar]
  53. Ludwig M., Vidal A., Diemer T., Pabst W., Failing K., Weidner W. 2002; Seminal secretory capacity of the male accessory sex glands in chronic pelvic pain syndrome (CPPS)/chronic prostatitis with special focus on the new prostatitis classification. Eur Urol 42:24–28 [View Article][PubMed]
    [Google Scholar]
  54. Mahmoud A. M., Geslevich J., Kint J., Depuydt C., Huysse L., Zalata A., Comhaire F. H. 1998; Seminal plasma alpha-glucosidase activity and male infertility. Hum Reprod 13:591–595 [View Article][PubMed]
    [Google Scholar]
  55. Marconi M., Pilatz A., Wagenlehner F., Diemer T., Weidner W. 2009; Impact of infection on the secretory capacity of the male accessory glands. Int Braz J Urol 35:299–308, discussion 308–309 [View Article][PubMed]
    [Google Scholar]
  56. Martínez P., Proverbio F., Camejo M. I. 2007; Sperm lipid peroxidation and pro-inflammatory cytokines. Asian J Androl 9:102–107 [View Article][PubMed]
    [Google Scholar]
  57. Meares E. M., Stamey T. A. 1968; Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol 5:492–518[PubMed]
    [Google Scholar]
  58. Murray P. R., Baron E. J., Jorgensen J. H. et al. (editors) 2003 Manual of Clinical Microbiology, 8th edn. Washington, DC: American Society for Microbiology;
    [Google Scholar]
  59. Nickel J. C. 1997; The Pre and Post Massage Test (PPMT): a simple screen for prostatitis. Tech Urol 3:38–43[PubMed]
    [Google Scholar]
  60. Nickel J. C., Nyberg L. M., Hennenfent M. 1999; Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology 54:229–233 [View Article][PubMed]
    [Google Scholar]
  61. Nickel J. C., Shoskes D., Wang Y., Alexander R. B., Fowler J. E. Jr, Zeitlin S., O’Leary M. P., Pontari M. A., Schaeffer A. J. other authors 2006; How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome?. J Urol 176:119–124 [View Article][PubMed]
    [Google Scholar]
  62. Okamura N., Tajima Y., Ishikawa H., Yoshii S., Koiso K., Sugita Y. 1986; Lowered levels of bicarbonate in seminal plasma cause the poor sperm motility in human infertile patients. Fertil Steril 45:265–272[PubMed]
    [Google Scholar]
  63. Omu A. E., Al-Qattan F., Al-Abdul-Hadi F. M., Fatinikun M. T., Fernandes S. 1999; Seminal immune response in infertile men with leukocytospermia: effect on antioxidant activity. Eur J Obstet Gynecol Reprod Biol 86:195–202 [View Article][PubMed]
    [Google Scholar]
  64. Orellana M. A., Gómez Ml., Sánchez M. T., Fernández-Chacón T. 2009; [Diagnosis of urethritis in men. A 3-year review]. Rev Esp Quimioter 22:83–87 (in Spanish) [PubMed]
    [Google Scholar]
  65. Pakendorf U. W., Bornman M. S., Du Plessis D. J. 1998; Prevalence of human papilloma virus in men attending the infertility clinic. Andrologia 30:11–14 [View Article][PubMed]
    [Google Scholar]
  66. Patel S. R., Wiese W., Patel S. C., Ohl C., Byrd J. C., Estrada C. A. 2000; Systematic review of diagnostic tests for vaginal trichomoniasis. Infect Dis Obstet Gynecol 8:248–257 [View Article][PubMed]
    [Google Scholar]
  67. Perdichizzi A., Nicoletti F., La Vignera S., Barone N., D’Agata R., Vicari E., Calogero A. E. 2007; Effects of tumour necrosis factor-alpha on human sperm motility and apoptosis. J Clin Immunol 27:152–162 [View Article][PubMed]
    [Google Scholar]
  68. Quintar A. A., Roth F. D., Paul A. L. D, Aoki A., Maldonado C. A. 2006; Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells. Biol Reprod 75:664–672 [View Article][PubMed]
    [Google Scholar]
  69. Rowe P., Comhaire F., Hargreave T. B., Mellows H. J. (editors) 1993 World Health Organization Manual for the Standardised Investigation and Diagnosis of the Infertile Couple Cambridge: Cambridge University Press;
    [Google Scholar]
  70. Rusz A., Pilatz A., Wagenlehner F., Linn T., Diemer T., Schuppe H. C., Lohmeyer J., Hossain H., Weidner W. 2012; Influence of urogenital infections and inflammation on semen quality and male fertility. World J Urol 30:23–30 [View Article][PubMed]
    [Google Scholar]
  71. Saraniya A., Koner B. C., Doureradjou P., Selvaraj N., Shivagourou V. 2008; Altered malondialdehyde, protein carbonyl and sialic acid levels in seminal plasma of microscopically abnormal semen. Andrologia 40:56–57 [View Article][PubMed]
    [Google Scholar]
  72. Schiefer H. G. 1998; Microbiology of male urethroadnexitis: diagnostic procedures and criteria for aetiologic classification. Andrologia 30:Suppl 17–13 [View Article][PubMed]
    [Google Scholar]
  73. Scottish Intercollegiate Guideline Network. Management of genital chlamydia trachomatis infection. A national clinical guideline. The Scottish Intercollegiate Guideline Network; 2009
    [Google Scholar]
  74. Sikka S. C., Champion H. C., Bivalacqua T. J., Estrada L. S., Wang R., Rajasekaran M., Aggarwal B. B., Hellstrom W. J. 2001; Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa. Int J Androl 24:136–141 [View Article][PubMed]
    [Google Scholar]
  75. Suleiman S. A., Ali M. E., Zaki Z. M., el-Malik E. M., Nasr M. A. 1996; Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl 17:530–537[PubMed]
    [Google Scholar]
  76. Twigg J. P., Irvine D. S., Aitken R. J. 1998; Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod 13:1864–1871 [View Article][PubMed]
    [Google Scholar]
  77. Vázquez F., Carreño F., Pérez A. F., Cuestan M. M., Ordóñez M. L., Palacio V. 1995; Comparison of 3 culture methods for genital mycoplasmas. Enferm Infecc Microbiol Clin 13:460–463 [View Article][PubMed]
    [Google Scholar]
  78. Vesić S., Vukićević J., Daković Z., Tomović M., Dobrosavljević D., Medenica L., Pavlović M. D. 2007; Male urethritis with and without discharge: relation to microbiological findings and polymorphonuclear counts. Acta Dermatovenerol Alp Panonica Adriat 16:53–57[PubMed]
    [Google Scholar]
  79. Vicari E. 1999; Seminal leukocyte concentration and related specific reactive oxygen species production in patients with male accessory gland infections. Hum Reprod 14:2025–2030 [View Article][PubMed]
    [Google Scholar]
  80. Vicari E., Mongioì A., Speciale A., Caccamo F., Calogero A., Gulizia S., Pellegrino M. B., Macchi M., D’Agata R. 1986; Enhancing detection of gonococcus in ejaculates of adult males using sperm dilution. Arch Androl 16:19–23 [View Article][PubMed]
    [Google Scholar]
  81. Vicari E., La Vignera S., Castiglione R., Calogero A. E. 2006; Sperm parameter abnormalities, low seminal fructose and reactive oxygen species overproduction do not discriminate patients with unilateral or bilateral post-infectious inflammatory prostato-vesiculo-epididymitis. J Endocrinol Invest 29:18–25[PubMed] [CrossRef]
    [Google Scholar]
  82. Wagenlehner F. M., Naber K. G. 2006; Current challenges in the treatment of complicated urinary tract infections and prostatitis. Clin Microbiol Infect 12:Suppl 367–80 [View Article][PubMed]
    [Google Scholar]
  83. Weidner W., Krause W., Ludwig M. 1999; Relevance of male accessory gland infection for subsequent fertility with special focus on prostatitis. Hum Reprod Update 5:421–432 [View Article][PubMed]
    [Google Scholar]
  84. Wincek T. J., Meyer T. K., Meyer M. R., Kuehl T. J. 1991; Absence of a direct effect of recombinant tumor necrosis factor-alpha on human sperm function and murine preimplantation development. Fertil Steril 56:332–339[PubMed]
    [Google Scholar]
  85. Zermann D. H., Wunderlich H., Schubert J., Ishigooka M. 1999; Re: The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database Study. J Urol 162:807 [View Article][PubMed]
    [Google Scholar]
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